Juan F. O.
- Country
- Ireland
- Department
- Neurology
Research Overview
- Evaluation of BMS-986446, an Anti-MTBR Tau Monoclonal Antibody, in Early Alzheimer's Disease: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study
- Evaluation of Remternetug (LY3372993) Versus Placebo in Early Alzheimer's Disease Patients at Risk for Cognitive and Functional Decline
- I5T-MC-AACO: Global Study to Investigate Safety and Efficacy of Donanemab in Early Symptomatic Alzheimer’s Disease
Data & Insights
Has run more than one trial at 8 of 39 partner sites.
Specializations
Alzheimer’s disease and cognitive disorders
Juan Fortea Ormaechea is involved in clinical research focused on Alzheimer’s disease, mild cognitive impairment, dementia, and related neurodegenerative diseases, with additional interest in Down syndrome-associated Alzheimer’s disease and other neurocognitive disorders.
- Preclinical Alzheimer’s disease
- Early symptomatic Alzheimer’s disease
- Autosomal dominant Alzheimer’s disease
- Parkinson’s disease
His research landscape also includes tauopathies, frontotemporal-spectrum conditions, and broader central nervous system diseases linked to memory and cognition.
Cardiovascular medicine and thromboembolic disease
He is active in studies addressing atherosclerotic cardiovascular disease, myocardial infarction, heart failure, atrial fibrillation, and stroke, with a strong therapeutic emphasis on prevention and secondary risk reduction.
- Acute coronary syndrome
- Ischemic stroke prevention
- Cardioembolic event prevention
- Lipoprotein(a)-related risk
His trial portfolio also covers hypertension, dyslipidemia, and cardiovascular pathology in high-risk populations.
Oncology and hematologic malignancies
His clinical research includes a broad range of solid tumors and blood cancers, with repeated involvement in lung cancer, breast cancer, colorectal cancer, prostate cancer, and renal cell carcinoma.
- Non-small cell lung cancer
- Multiple myeloma
- Diffuse large B-cell lymphoma
- Acute myeloid leukemia
He is also engaged in research on melanoma, urothelial carcinoma, gastrointestinal tumors, and sarcomas.
Autoimmune, inflammatory, and allergic diseases
His therapeutic interests extend to systemic lupus erythematosus, cutaneous lupus erythematosus, systemic sclerosis, rheumatoid arthritis, and psoriatic disease, reflecting active participation in immune-mediated disease research.
- Atopic dermatitis
- Chronic spontaneous urticaria
- Hidradenitis suppurativa
- Inflammatory myopathies
His portfolio also includes asthma, allergic rhinitis, and other immune system diseases with chronic inflammatory burden.
Neurology, psychiatry, and rare disorders
He contributes to studies in epilepsy, multiple sclerosis, myasthenia gravis, amyotrophic lateral sclerosis, and selected movement disorders, alongside psychiatric research in major depressive disorder and schizophrenia.
- Focal epilepsy
- Refractory status epilepticus
- Treatment-resistant depression
- Schizophrenia
His work also reaches rare genetic and neurodevelopmental conditions, including Huntington’s disease, Dravet syndrome, and Lennox-Gastaut syndrome.
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