Juan Carlos Lopez B. D. Q.
- Country
- Spain
- Department
- Infectious Diseases Unit
Research Overview
- Evaluation of Dolutegravir/Lamivudine and Cabotegravir/Rilpivirine for Virologic Suppression in Antiretroviral-Naive HIV-1 Infected Adults
- A Phase 3 Open-label Clinical Study of Doravirine/Islatravir (DOR/ISL [100 mg/0.25 mg]) Once Daily for the Treatment of HIV-1 Infection in Participants Who Previously Received DOR/ISL (100 mg/0.75 mg) QD in a Phase 3 Clinical Study
- Phase 3 Randomized Double‑Blind Study of Doravirine/Islatravir Versus Bictegravir Combination Therapy in Treatment‑Naïve HIV‑1 Infection
Data & Insights
Has run more than one trial at 34 of 67 partner sites.
Specializations
Infectious Diseases and Antimicrobial Therapy
Clinical research in the Infectious Diseases Unit spans management of complex bacterial, viral, and opportunistic infections, with attention to HIV infection, hepatitis, Clostridioides difficile infection, invasive candidiasis, and infective endocarditis.
- HIV-1 infection
- Chronic hepatitis B and hepatitis D
- Severe bacterial infections
- Invasive fungal infections
- Vaccine-preventable respiratory infection
Additional activity includes studies in COVID-19, community-acquired pneumonia, and infection prevention in immunocompromised settings.
Oncology and Hematologic Malignancies
The investigator is involved in trials across a broad oncology portfolio, including solid tumors, breast cancer, lung cancer, gastrointestinal cancers, and multiple blood cancers such as lymphoma, leukemia, and multiple myeloma.
- Non-small cell lung cancer
- Breast cancer
- Colorectal cancer
- Diffuse large B-cell lymphoma
- Acute myeloid leukemia
Research also includes melanoma, hepatocellular carcinoma, urothelial carcinoma, pancreatic cancer, and sarcoma, reflecting interest in advanced and molecularly defined malignancies.
Autoimmune, Inflammatory, and Immune-Mediated Disorders
Clinical work extends to immune-driven diseases affecting the skin, joints, connective tissue, and gastrointestinal tract, with studies in atopic dermatitis, psoriasis, hidradenitis suppurativa, rheumatoid arthritis, and inflammatory bowel disease.
- Systemic lupus erythematosus
- Crohn's disease and ulcerative colitis
- Psoriatic arthritis
- Sjögren’s syndrome
- Immune thrombocytopenia
Additional interests include systemic sclerosis, idiopathic inflammatory myopathies, and autoimmune cytopenias.
Liver Disease, Renal Disease, and Metabolic Disorders
Another major area focuses on chronic organ disease, particularly metabolic dysfunction-associated steatohepatitis, primary biliary cholangitis, cirrhosis, chronic kidney disease, and immunoglobulin A nephropathy.
- Non-alcoholic steatohepatitis
- Primary sclerosing cholangitis
- Chronic kidney disease
- Type 2 diabetes
- Obesity and cardiovascular disease
Research also includes cholestatic pruritus, liver fibrosis, and heart failure linked to cardiometabolic risk.
Respiratory, Cardiovascular, and Neurologic Disorders
The investigator’s portfolio includes studies in asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, pulmonary arterial hypertension, and bronchiectasis, alongside cardiovascular and neurologic conditions.
- Acute ischemic stroke
- Myocardial infarction
- Heart failure
- Multiple sclerosis
- Parkinson’s disease
Additional trial activity covers thrombotic disorders, cardiomyopathy, and selected neuroinflammatory diseases.
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