Josefina C. H.
- Country
- Spain
- Department
- Rheumatology
Research Overview
- Evaluation of Long-Term Safety and Efficacy of Litifilimab in Adults with Active Systemic Lupus Erythematosus: A Phase 3 Multicenter, Randomized, Dose-Blind Study
- Long-Term Safety and Efficacy Evaluation of Litifilimab (BIIB059) in Adults with Active Subacute or Chronic Cutaneous Lupus Erythematosus
- Evaluation of Cenerimod Efficacy and Safety in Adults with Moderate-to-Severe Systemic Lupus Erythematosus: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study
Data & Insights
Has run more than one trial at 106 of 241 partner sites.
Specializations
Rheumatology and systemic autoimmune disease
Clinical research activity in rheumatology includes immune-mediated inflammatory disorders with a focus on systemic lupus erythematosus, rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, and juvenile idiopathic arthritis. Interest also extends to multisystem autoimmune conditions such as Behçet’s disease, systemic sclerosis, and Sjögren’s disease.
- Systemic lupus erythematosus
- Rheumatoid arthritis
- Psoriatic arthritis
- Systemic sclerosis
- Juvenile idiopathic arthritis
The therapeutic profile reflects involvement in advanced immune modulation for chronic inflammatory disease and connective tissue disorders.
Oncology and solid tumor therapeutics
The trial portfolio shows strong engagement in oncology, especially breast cancer, non-small cell lung cancer, colorectal cancer, ovarian cancer, urothelial carcinoma, and renal cell carcinoma. Additional interest includes gastrointestinal malignancies, head and neck squamous cell carcinoma, and biomarker-defined advanced solid tumors.
- Breast cancer
- Non-small cell lung cancer
- Colorectal cancer
- Ovarian cancer
- Urothelial carcinoma
Research activity is centered on targeted and immunologic approaches across advanced and metastatic malignancies.
Hematologic malignancies and cellular therapy
Clinical research also covers hematologic malignancies, including acute myeloid leukemia, multiple myeloma, diffuse large B-cell lymphoma, follicular lymphoma, chronic lymphocytic leukemia, and mantle cell lymphoma. The landscape includes interest in graft-versus-host disease and other post-transplant immune complications.
- Acute myeloid leukemia
- Multiple myeloma
- Diffuse large B-cell lymphoma
- Chronic lymphocytic leukemia
- Graft-versus-host disease
The therapeutic emphasis includes novel blood cancer strategies and immune-directed treatment for refractory disease.
Neuroimmunology and neurologic disease
Research interests include myasthenia gravis, multiple sclerosis, epilepsy, Parkinson’s disease, and Alzheimer’s disease. The portfolio also touches on complex inflammatory and neurodegenerative conditions that require specialized therapeutic development.
- Myasthenia gravis
- Multiple sclerosis
- Epilepsy
- Parkinson’s disease
- Alzheimer’s disease
This area reflects involvement in therapies for immune-mediated neurologic disorders and progressive nervous system disease.
Organ-specific inflammatory and cardiometabolic disease
Additional clinical trial activity spans pulmonary arterial hypertension, chronic kidney disease, lupus nephritis, idiopathic pulmonary fibrosis, asthma, and atherosclerotic cardiovascular disease. The portfolio also includes liver-related and metabolic disorders such as metabolic dysfunction-associated steatohepatitis and obesity.
- Pulmonary arterial hypertension
- Chronic kidney disease
- Lupus nephritis
- Idiopathic pulmonary fibrosis
- Atherosclerotic cardiovascular disease
The therapeutic scope includes chronic organ protection, inflammation control, and disease-modifying care across cardiopulmonary and renal conditions.
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