Valentin G. G.
- Country
- Spain
- Department
- Hematology
Research Overview
- Phase 1 Study of AJ1-11095 in Adults with Myelofibrosis Refractory to JAK2 Inhibitors
- Safety and Efficacy of Ponatinib Plus Asciminib Combination in Chronic Myeloid Leukemia Patients with Resistance to Ponatinib and/or Asciminib
- Phase 1 Study of PRT12396 in Patients with High‑Risk Polycythemia Vera and Post‑ET or Post‑PV Myelofibrosis and Intermediate/High‑Risk Primary Myelofibrosis
Data & Insights
Has run more than one trial at 145 of 268 partner sites.
Specializations
Hematologic malignancies
Clinical research in acute myeloid leukemia, myelodysplastic syndromes, multiple myeloma, and lymphoma across relapsed, refractory, and newly diagnosed settings, with interest in transplant-linked treatment strategies and disease control.
- Acute myeloid leukemia
- Multiple myeloma
- Diffuse large B-cell lymphoma
- Myelofibrosis
- Chronic lymphocytic leukemia
Work also extends to graft-versus-host disease and stem cell transplantation in the context of blood cancers and immune-mediated complications.
Solid tumors and precision oncology
Active involvement in trials for breast cancer, non-small cell lung cancer, urothelial carcinoma, renal cell carcinoma, ovarian cancer, colorectal cancer, and gastroesophageal cancers, including biomarker-defined and metastatic disease.
- Breast cancer
- Non-small cell lung cancer
- Urothelial carcinoma
- Renal cell carcinoma
- Endometrial cancer
Therapeutic interest includes HER2-directed approaches, immune checkpoint inhibition, and targeted treatment for molecularly selected tumors.
Autoimmune and inflammatory disorders
Research activity includes systemic lupus erythematosus, rheumatoid arthritis, juvenile idiopathic arthritis, myasthenia gravis, Sjögren’s disease, and Behçet’s disease, reflecting a strong focus on immune-mediated disease.
- Systemic lupus erythematosus
- Myasthenia gravis
- Juvenile idiopathic arthritis
- Sjögren’s disease
- Bullous pemphigoid
Additional interest is seen in thyroid eye disease, psoriasis, and other chronic inflammatory skin and organ-specific autoimmune conditions.
Cardiovascular and metabolic disease
Clinical trial involvement spans atherosclerotic cardiovascular disease, heart failure, myocardial infarction, stroke prevention, pulmonary hypertension, obesity, and type 2 diabetes mellitus.
- Atherosclerotic cardiovascular disease
- Heart failure
- Myocardial infarction
- Pulmonary arterial hypertension
- Type 2 diabetes mellitus
Work also includes dyslipidemia, familial hypercholesterolemia, and cardiometabolic risk reduction in high-risk patient populations.
Neurology, respiratory, and liver disease
Research interests further cover multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, epilepsy, asthma, chronic obstructive pulmonary disease, nonalcoholic steatohepatitis, and cirrhosis.
- Multiple sclerosis
- Parkinson’s disease
- Alzheimer’s disease
- Asthma
- Cirrhosis
Additional therapeutic focus includes hepatic encephalopathy, acute liver failure, and fibrosing lung disease.
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