Jose Luis D.
- Country
- Spain
- Department
- Pediatrics
Research Overview
- International proof of concept therapeutic Stratification trial of Molecular Anomalies in Relapsed or Refractory HEMatological malignancies in children - Sub-protocol D
- ALLTogether1 - A Treatment Study Protocol of the ALLTogether Consortium for Children and Young Adults (0-45 Years of Age) with Newly Diagnosed Acute Lymphoblastic Leukaemia (ALL)
- Phase I/II Study of Ruxolitinib and Venetoclax in Pediatric Relapsed/Refractory Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma with IL-7R/JAK-STAT Mutations
Data & Insights
Has run more than one trial at 56 of 155 partner sites.
Specializations
Paediatric haematology and leukaemia
Clinical research activity centres on childhood and adolescent acute lymphoblastic leukaemia, acute myeloid leukaemia, and related lymphoid malignancies, with additional involvement in lymphoma and other haematologic cancers.
- Acute lymphoblastic leukaemia
- Acute myeloid leukaemia
- Relapsed or refractory lymphoma
- Pediatric and young adult haematologic malignancies
Work in this area includes therapeutic interest in targeted oncology, immunotherapy, and treatment strategies for high-risk or relapsed disease.
Childhood cancers and solid tumours
The investigator is involved in studies of neuroblastoma, sarcomas, brain tumours, and other paediatric solid tumours, including aggressive and refractory forms of disease.
- Neuroblastoma
- Ewing sarcoma and rhabdomyosarcoma
- Diffuse glioma and ependymoma
- Wilms tumour and hepatoblastoma
Therapeutic interests extend to radioligand therapy, novel antineoplastic agents, and approaches for refractory paediatric oncology.
Immune-mediated and inflammatory disorders
Research involvement includes juvenile idiopathic arthritis, systemic lupus erythematosus, Crohn's disease, ulcerative colitis, psoriasis, and atopic dermatitis, reflecting a strong focus on chronic immune-driven disease in children.
- Juvenile idiopathic arthritis
- Inflammatory bowel disease
- Atopic dermatitis and psoriasis
- Lupus nephritis and systemic lupus erythematosus
Therapeutic domains include biologic therapies, JAK inhibition, and other anti-inflammatory treatments used across paediatric immune disorders.
Neurology, genetic disease, and rare disorders
Clinical trial activity also covers epileptic encephalopathies, tuberous sclerosis complex, spinal muscular atrophy, Duchenne muscular dystrophy, and inherited metabolic and neurodevelopmental conditions.
- Developmental and epileptic encephalopathies
- Tuberous sclerosis complex
- Spinal muscular atrophy
- Inherited metabolic and lysosomal disorders
Additional therapeutic interest includes gene therapy, enzyme-related disorders, and orphan disease treatments for paediatric rare conditions.
Respiratory, infectious, and supportive care medicine
The investigator is active in studies of asthma, cystic fibrosis, respiratory infections, sepsis, and antimicrobial therapy, alongside selected cardiovascular and renal conditions relevant to paediatric care.
- Severe asthma and allergic disease
- Respiratory syncytial virus infection and pneumonia
- Serious bacterial infections
- Heart failure and pulmonary arterial hypertension
These interests include anti-infective therapies, respiratory biologics, and supportive treatments for medically complex children.
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