Joris H.
- Country
- The Netherlands
- Department
- Emergency Department
Research Overview
Data & Insights
Has run more than one trial at 0 of 8 partner sites.
Specializations
Cardiovascular Medicine
Investigator concentrates on acute and chronic heart and vessel disorders, such as acute myocardial infarction and atrial fibrillation, as well as peripheral circulation disease.
- Acute coronary syndromes
- Heart failure with renal impairment
- Peripheral arterial disease
- Stroke prevention in atrial fibrillation
- Lipid‑lowering strategies for atherosclerotic disease
Efforts target reduction of major adverse cardiovascular events and enhancement of long‑term cardiovascular health.
Oncology
Research activities span solid and hematologic malignancies, including non‑small cell lung cancer, breast cancer, and multiple myeloma.
- Targeted therapy in lung cancer
- Immunotherapy for urothelial carcinoma
- HER2‑positive esophageal and gastric cancers
- Relapsed/refractory lymphoma
- Adjuvant treatment strategies in early‑stage cancers
Focus is on improving survival outcomes and defining optimal combination regimens.
Metabolic & Endocrine Disorders
Investigator addresses metabolic risk factors, notably type 2 diabetes mellitus and dyslipidaemia, alongside obesity‑related conditions.
- Glycaemic control in high‑risk diabetic patients
- Management of severe hypertriglyceridaemia
- Statin intolerance and alternative lipid‑lowering agents
- Obesity and overweight interventions
- Primary prevention of atherosclerotic cardiovascular disease
Goals include mitigating cardiovascular risk through metabolic optimisation.
Pulmonary & Critical Care
Clinical focus includes acute respiratory conditions such as severe asthma with eosinophilic phenotype and infectious pulmonary diseases.
- Management of eosinophilic severe asthma
- Treatment of community‑acquired pneumonia
- Ventilator weaning strategies
- Respiratory distress oxygen‑saturation targets
- Chronic obstructive pulmonary disease exacerbations
Research aims to improve respiratory outcomes and reduce intensive care burden.
Hematology & Immunology
Investigator engages in studies of blood‑cell malignancies, including acute myeloid leukaemia and chronic lymphocytic leukaemia, as well as immune‑mediated disorders.
- Novel agents for acute myeloid leukaemia
- Combination regimens in chronic lymphocytic leukaemia
- Therapies for myelodysplastic syndromes
- Immune modulation in multiple sclerosis
- Management of autoimmune inflammatory bowel disease
Efforts target disease modification and durable remission in hematologic and immune conditions.
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