Joos R.
- Country
- Belgium
- Department
- Rheumatology
Research Overview
- Safety, Tolerability, Pharmacokinetics, and Efficacy of Filgotinib in Children and Adolescents with Polyarticular-Course Juvenile Idiopathic Arthritis
- Baricitinib Versus TNF Inhibitors for Venous Thromboembolism Risk in Rheumatoid Arthritis: Phase 3b/4 Active-Controlled Study
- A multicenter, randomized open-label study to assess the efficacy, safety, and pharmacokinetics of upadacitinib with a tocilizumab reference arm in subjects from 1 year to less than 18 years old with active systemic juvenile idiopathic arthritis.
Data & Insights
Has run more than one trial at 27 of 181 partner sites.
Specializations
Autoimmune & Inflammatory Disorders
Focus on chronic immune‑mediated conditions affecting joints and systemic tissues.
- Rheumatoid Arthritis
- Juvenile psoriatic arthritis
- Peripheral spondyloarthritis
- Inflammatory bowel disease
- Systemic lupus erythematosus
Research integrates biomarkers to stratify patients for targeted biologic therapy in Rheumatoid Arthritis and related diseases.
Hematologic Malignancies
Investigation of blood‑derived cancers spanning acute, chronic and lymphoid lineages.
- Acute myeloid leukemia
- Myelodysplastic syndromes
- Chronic lymphocytic leukemia
- Multiple myeloma
- Diffuse large B‑cell lymphoma
- Mantle cell lymphoma
- Chronic myeloid leukemia
Efforts emphasize disease‑modifying strategies and assessment of transplant eligibility for Acute myeloid leukemia and related disorders.
Solid Tumor Oncology
Broad engagement with malignant solid neoplasms across multiple organ systems.
- Breast cancer
- Non‑small cell lung cancer
- Prostate cancer
- Colorectal cancer
- Bladder cancer
- Ovarian carcinoma
- Melanoma
Collaboration with surgical and radiation specialties expands multimodal treatment evaluation for Breast cancer and other solid tumors.
Cardiovascular & Thrombotic Disorders
Targeted research on arterial and venous conditions that drive morbidity and mortality.
- Atrial fibrillation
- Atherosclerotic cardiovascular disease
- Coronary artery disease
- Stroke
- Venous thromboembolism
- Elevated lipoprotein(a)
Studies target risk reduction through antithrombotic and lipid‑lowering interventions in patients with Atrial fibrillation and related conditions.
Pulmonary Fibrotic Diseases
Focused on progressive interstitial lung disorders characterized by fibrotic remodeling.
- Idiopathic pulmonary fibrosis
- Progressive fibrosing interstitial lung disease
Long‑term safety and functional outcomes are central endpoints for therapies addressing Idiopathic pulmonary fibrosis.
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