Jonel T.
- Country
- Germany
- Department
- Gastroenterologie; Hepatologie, Endokrinologie, Klinische Infektiologie
Research Overview
- Biomarker‑Guided Personalized Human Serum Albumin Therapy in Decompensated Cirrhosis with Ascites: A Multinational Randomized Controlled Trial
- Phase II Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Vixarelimab in Patients with Moderate to Severe Ulcerative Colitis
- Non‑inferiority, adaptive, double‑blind trial of short‑course versus standard 14‑day caspofungin acetate therapy in adults with uncomplicated candidemia (CanTEN)
Data & Insights
Has run more than one trial at 198 of 485 partner sites.
Specializations
Hematologic Malignancies and Cellular Therapy
Clinical research activity includes a broad focus on acute myeloid leukemia, acute lymphoblastic leukemia, diffuse large B-cell lymphoma, mantle cell lymphoma, and other aggressive lymphoid and myeloid neoplasms, with additional involvement in multiple myeloma, Waldenström’s macroglobulinemia, and myelodysplastic syndromes.
- Acute myeloid leukemia
- Diffuse large B-cell lymphoma
- Multiple myeloma
Research interests also extend to hematopoietic stem cell transplantation, graft-versus-host disease, and transplant-related infection risk in blood cancer care.
Gastroenterology, Hepatology, and Liver Failure
The investigator is active in clinical studies of cirrhosis, portal hypertension, acute-on-chronic liver failure, hepatic encephalopathy, and cholestatic liver disease, with attention to advanced liver dysfunction and complications of decompensation.
- Cirrhosis
- Portal hypertension
- Acute-on-chronic liver failure
Further involvement includes primary sclerosing cholangitis, primary biliary cholangitis, metabolic dysfunction-associated steatotic liver disease, and hepatocellular carcinoma.
Autoimmune and Inflammatory Diseases
Research spans systemic lupus erythematosus, atopic dermatitis, psoriasis, hidradenitis suppurativa, chronic urticaria, and other immune-mediated skin and systemic disorders, reflecting a strong therapeutic interest in inflammatory disease control.
- Systemic lupus erythematosus
- Atopic dermatitis
- Psoriasis
Additional areas include bullous pemphigoid, vitiligo, thyroid eye disease, and myasthenia gravis.
Solid Tumors and Genitourinary Oncology
Clinical trial involvement covers breast cancer, prostate cancer, non-small cell lung cancer, ovarian cancer, bladder cancer, and urothelial carcinoma, with a clear emphasis on advanced and metastatic disease settings.
- Breast cancer
- Prostate cancer
- Non-small cell lung cancer
Other interests include melanoma, head and neck squamous cell carcinoma, endometrial cancer, and renal cell carcinoma.
Neurology, Pediatric Disorders, and Transplant Medicine
The investigator also participates in studies of multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, ischemic stroke, and treatment-resistant depression, alongside pediatric and rare-disease programs.
- Multiple sclerosis
- Alzheimer’s disease
- Ischemic stroke
Additional therapeutic areas include pediatric leukemia, neuroblastoma, atypical teratoid/rhabdoid tumour, retinopathy of prematurity, and kidney transplantation.
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