John D.
- Country
- Greece
- Department
- Diabetes Division
Research Overview
- Effect of Orforglipron on Major Adverse Cardiovascular Events in Patients With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease
- Randomized Study of Cagrilintide + Semaglutide Combination vs Semaglutide Monotherapy for Weight Loss in Adults with Obesity (± Type 2 Diabetes)
- Phase III Randomized Double‑Blind Study of Elecoglipron Plus Dapagliflozin Versus Elecoglipron or Dapagliflozin Monotherapy in Adults with Type 2 Diabetes Mellitus
Data & Insights
Has run more than one trial at 284 of 864 partner sites.
Specializations
Metabolic and Endocrine Disorders
Investigator concentrates on the treatment of type 2 diabetes and its metabolic sequelae.
- Glycaemic control strategies
- Obesity and overweight management
- Prevention of diabetic complications
Efforts integrate lifestyle and pharmacologic approaches to improve long‑term outcomes.
Cardiovascular and Renal Therapeutics
Research targets atherosclerotic cardiovascular disease and associated renal impairment.
- Hypertension control
- Heart failure with reduced or preserved ejection fraction
- Chronic kidney disease and inflammation
Studies aim to lower major adverse cardiovascular events while protecting renal function.
Oncology – Solid Tumors
Investigator is active in clinical programs for multiple solid tumors, especially lung and breast cancers.
- Non‑small cell lung cancer
- Hormone‑receptor positive breast cancer
- Melanoma and metastatic disease
- Bladder and urothelial carcinoma
Focus includes targeted therapies, immunotherapy combinations, and disease‑specific biomarkers.
Respiratory and Pulmonary Diseases
Work encompasses chronic airway disorders such as asthma and chronic obstructive pulmonary disease.
- Severe uncontrolled asthma
- Moderate to very severe COPD
- Bronchiectasis with chronic infection
Therapeutic goals involve reducing exacerbations and preserving lung function.
Neurological and Autoimmune Conditions
Investigator also explores treatments for neuro‑degenerative and autoimmune diseases.
- Agitation in Alzheimer’s disease
- Cutaneous lupus erythematosus
- Ulcerative colitis
- Primary progressive multiple sclerosis
Research seeks to modulate immune pathways and improve quality of life.
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