Johannes V.
- Country
- The Netherlands
- Department
- Medical Oncology
Research Overview
- Phase 1 Evaluation of JNJ-87189401 and JNJ-78278343 in Patients with Advanced Prostate Cancer
- Phase 1 Study of CVX1 Vaccine With or Without Immune Checkpoint Inhibitors in Muscle Invasive Bladder Cancer or Localized/Locally Advanced Renal Cell Cancer
- A Phase 3 Study of MK-2870 Versus Investigator’s Choice of Non-platinum Chemotherapy in Participants with Pretreated Locally Advanced or Metastatic Urothelial Carcinoma
Data & Insights
Has run more than one trial at 120 of 284 partner sites.
Specializations
Genitourinary Oncology
Clinical research in urothelial carcinoma, bladder cancer, upper tract urothelial carcinoma, and prostate cancer, with additional interest in renal cell carcinoma and kidney cancer.
- Muscle-invasive bladder cancer
- Metastatic prostate cancer
- Advanced urothelial carcinoma
- Renal cell carcinoma
Work in this area also includes molecular imaging for prostate malignancy and perioperative treatment strategies in urothelial disease.
Gastrointestinal and Hepatobiliary Cancer
Therapeutic activity spans pancreatic cancer, colorectal cancer, gastric cancer, cholangiocarcinoma, and other hepatobiliary malignancies.
- Pancreatic ductal adenocarcinoma
- Metastatic colorectal cancer
- Cholangiocarcinoma
- Gastric and gastroesophageal junction cancer
The portfolio reflects a strong focus on advanced solid tumors and treatment options for difficult-to-resect gastrointestinal cancers.
Thoracic and Head and Neck Oncology
Research involvement includes non-small cell lung cancer, small cell lung cancer, esophageal cancer, and head and neck squamous cell carcinoma.
- Advanced non-small cell lung cancer
- Extensive-stage small cell lung cancer
- Esophageal squamous cell carcinoma
- Locally advanced head and neck cancer
Interest extends to biomarker-defined thoracic disease and multimodal treatment approaches in locally advanced and metastatic settings.
Hematologic Malignancies
Clinical trial activity covers lymphoma, multiple myeloma, acute leukemia, and other B-cell malignancies.
- Diffuse large B-cell lymphoma
- Relapsed or refractory multiple myeloma
- Chronic lymphocytic leukemia
- Acute myeloid leukemia
This area includes interest in cellular and targeted therapies for relapsed, refractory, and high-risk hematologic cancers.
Immune-Mediated and Renal Disease
Research also spans glomerular disease, inflammatory bowel disease, systemic sclerosis, lupus nephritis, and IgA nephropathy.
- IgA nephropathy
- C3 glomerulopathy
- Crohn’s disease
- Ulcerative colitis
Additional therapeutic interests include autoimmune disorders, transplant rejection, and cardiovascular risk linked to chronic inflammatory disease.
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