Johannes L.
- Country
- Germany
- Department
- Department of Psychiatry and Neurosciences
Research Overview
- Phase 2 Randomized, Double‑Blind, Placebo‑Controlled Trial of Intrathecal Mivelsiran (ALN‑961583) in Adults with Early‑Stage Down Syndrome‑Associated Alzheimer’s Disease
- Evaluation of Amyloid PET Imaging with Florbetaben (18F) and Flutemetamol (18F) in Dementia-Related Morbidity Outcomes
- Phase II Double-Blind, Randomized, Placebo-Controlled Study of Glycerol Phenylbutyrate on Neurofilament Light Chain Levels in Corticobasal Syndrome Patients
Data & Insights
Has run more than one trial at 67 of 120 partner sites.
Specializations
Neurodegenerative Disorders
The investigator specializes in the study of Dominantly Inherited Alzheimer Disease (DIAD), exploring innovative therapeutic approaches for early-onset cases linked to genetic mutations. Their research encompasses the evaluation of potential disease-modifying treatments aimed at slowing cognitive decline.
- Early-onset Alzheimer's Disease
- Genetic Mutation Analysis
- Disease-modifying Interventions
This work focuses on understanding disease progression through cognitive and biomarker assessments.
Movement Disorders
The investigator conducts research in Corticobasal Syndrome (CBS), investigating novel therapeutic approaches using glycerol phenylbutyrate. Their work includes monitoring neurofilament light chain levels as a key biomarker for disease progression.
- Biomarker Analysis
- Therapeutic Development
- Clinical Assessment Methods
Their research aims to advance treatment options for movement disorder patients.
Diagnostic Innovation
The investigator explores advanced diagnostic methodologies, particularly focusing on amyloid PET imaging in various forms of dementia. Their research encompasses multiple dementia types, including vascular dementia, Pick's disease, and Alzheimer's disease variants.
- Neuroimaging Techniques
- Differential Diagnosis
- Patient Care Optimization
This research aims to enhance diagnostic accuracy and patient outcomes in dementia care.
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