Johan K.
- Country
- France
- Department
- Radiothérapie
Research Overview
- De-escalation of endocrine therapy in postmenopausal women with low-risk HR+ HER2- low Luminal A early breast cancer: a single-arm study of omission versus combination therapy
- Evaluation of Reduced Duration of Adjuvant Endocrine Therapy with Exemestane, Anastrozole, and Letrozole in Postmenopausal Women with Low-Risk HR+ HER2- Breast Cancer
Data & Insights
Has run more than one trial at 17 of 69 partner sites.
Specializations
Radiation Oncology and Solid Tumor Care
Clinical research activity in radiotherapy spans the management of lung cancer, head and neck squamous cell carcinoma, colorectal cancer, rectal cancer, biliary tract carcinoma, hepatocellular carcinoma, and pancreatic adenocarcinoma, with attention to both locally advanced and metastatic disease.
- Non-small cell lung cancer
- Breast cancer
- Gastroesophageal adenocarcinoma
- Anal squamous cell carcinoma
Work also includes treatment strategies for kidney cancer, prostate cancer, and cutaneous squamous cell carcinoma, reflecting a strong focus on multimodality cancer care.
Breast Cancer and Molecularly Guided Therapy
Investigational interest includes HER2-positive breast cancer, HER2-negative breast cancer, triple-negative breast cancer, and hormone receptor-positive disease, with emphasis on recurrence prevention and treatment adaptation in early and advanced settings.
- Circulating tumor DNA
- Endocrine therapy
- Anti-HER2 targeted therapy
- PIK3CA/AKT1/PTEN-altered disease
The portfolio also covers molecular relapse, ESR1 mutation detection, and risk-adapted treatment intensification or de-escalation in breast cancer.
Hematologic Malignancies and Onco-Hematology
Research spans acute lymphoblastic leukemia, multiple myeloma, follicular lymphoma, mantle cell lymphoma, peripheral T-cell lymphoma, chronic lymphocytic leukemia, and myelodysplastic syndromes, with additional interest in myeloproliferative neoplasms and Waldenström macroglobulinemia.
- Relapsed/refractory lymphoma
- Transplant-ineligible myeloma
- Minimal residual disease
- Frontline leukemia therapy
Clinical activity also extends to autologous stem cell transplantation and treatment optimization for higher-risk blood cancers.
Autoimmune, Inflammatory, and Pulmonary Disorders
Therapeutic interests include giant cell arteritis, systemic sclerosis, lupus nephritis, vasculitis, dermatomyositis, immune thrombocytopenia, and psoriasis, alongside respiratory conditions such as severe asthma, chronic obstructive pulmonary disease, and interstitial lung disease.
- Eosinophilic asthma
- Granulomatosis with polyangiitis
- Asthma control
- Inflammatory connective tissue disease
Additional involvement includes migraine and chronic migraine care, broadening the non-oncologic therapeutic scope.
Infectious Disease, Cardiovascular, and Critical Care
Research activity also covers chronic hepatitis D infection, Mycobacterium avium complex, Mycobacterium xenopi pulmonary infection, Clostridioides difficile infection, ventilator-associated pneumonia, and prosthetic joint infection.
- Atrial fibrillation
- Hypertension
- Out-of-hospital cardiac arrest
- Cardiopulmonary outcomes
Additional interests include acute coronary syndrome, renal disease, and intensive care settings, reflecting engagement with complex internal medicine and acute care domains.
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