João S. C.
- Country
- Portugal
- Department
- Medical Oncology
Research Overview
Data & Insights
Has run more than one trial at 15 of 135 partner sites.
Specializations
Medical Oncology
Clinical research activity in Medical Oncology spans advanced solid malignancies and biomarker-driven cancer care, with a particular focus on breast cancer, gastric and gastroesophageal junction cancer, and non-small cell lung cancer.
- HER2-positive breast cancer
- HR-positive/HER2-negative breast cancer
- FGFR2b-overexpressing gastric cancer
- Metastatic non-small cell lung cancer
- Non-muscle-invasive urothelial carcinoma
Work in this area also includes treatment strategies for advanced solid tumors and metastatic colorectal cancer, reflecting interest in targeted and precision-based oncology.
Gastroenterology and Immune-Mediated Disease
Research involvement extends to inflammatory bowel disease and related immune-mediated disorders, especially Crohn’s disease and ulcerative colitis, alongside broader autoimmune conditions.
- Crohn’s disease
- Ulcerative colitis
- Primary sclerosing cholangitis
- Primary biliary cholangitis
- Systemic lupus erythematosus
Additional interest is seen in rheumatoid arthritis and lupus nephritis, underscoring a strong therapeutic presence in chronic inflammatory disease.
Cardiovascular and Metabolic Disease
Clinical activity includes a wide cardiovascular portfolio covering atherosclerotic cardiovascular disease, atrial fibrillation, heart failure, and pulmonary arterial hypertension, with emphasis on risk reduction and disease progression.
- Atherosclerotic cardiovascular disease
- Atrial fibrillation
- Heart failure with preserved ejection fraction
- Transthyretin amyloid cardiomyopathy
- Hypertension and obesity
Metabolic and hepatic interests also include type 2 diabetes and non-alcoholic steatohepatitis, linking cardiometabolic care with end-organ protection.
Neurology and Neuropsychiatry
Research involvement in neurology and neuropsychiatry includes disorders affecting cognition, movement, and seizure control, with attention to Alzheimer’s disease, Parkinson’s disease, and epilepsy.
- Alzheimer’s disease and psychosis
- Parkinson’s disease
- Focal-onset seizures
- Primary generalized tonic-clonic seizures
- Migraine
Additional activity covers mild cognitive impairment, agitation in dementia, and stroke-related spasticity, indicating engagement with both degenerative and vascular neurological conditions.
Respiratory, Dermatologic, and Other Chronic Conditions
Further trial involvement includes chronic obstructive pulmonary disease, severe asthma, and atopic dermatitis, together with inflammatory skin disease and selected rare disorders.
- Chronic obstructive pulmonary disease
- Severe asthma
- Psoriasis and hidradenitis suppurativa
- Atopic hand eczema
- Transthyretin amyloidosis
Interest also extends to overactive bladder, clostridioides difficile infection, and acute ischemic stroke, broadening the therapeutic scope across chronic and acute care domains.
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