Joana D.
- Country
- Portugal
- Department
- Neurology
Research Overview
Data & Insights
Has run more than one trial at 0 of 6 partner sites.
Specializations
Neurodegenerative Disorders
Research emphasizes therapeutic strategies for progressive proteinopathies affecting cognition and movement.
- Disease-modifying agents for Alzheimer’s disease
- Alpha-synuclein targeting in Parkinson’s disease
- Genetic therapies for Frontotemporal dementia
Efforts aim to alter disease trajectory and improve functional outcomes.
Neuroinflammatory and Autoimmune Disorders
Focus on immune-mediated conditions of the central and peripheral nervous system.
- B-cell depletion in multiple sclerosis
- Complement inhibition in generalized Myasthenia Gravis
- Cytokine blockade for MOG antibody-associated disease
Therapies target pathogenic autoantibodies and inflammatory pathways.
Pediatric Neurology and Developmental Encephalopathies
Investigations address rare early‑onset epilepsies and neurodevelopmental syndromes.
- Sodium channel modulators for Dravet syndrome
- Gene‑editing approaches for developmental and epileptic encephalopathies
- Disease‑specific interventions for spinocerebellar ataxia type 3
Aim to reduce seizure burden and support neurodevelopment.
Neurovascular and Cerebrovascular Disorders
Research targets acute and chronic vascular insults to the brain.
- Antithrombotic strategies after acute ischemic stroke
- Risk reduction in high‑risk transient ischemic attack
- Neuroprotective agents for post‑stroke recovery
Goals include prevention of recurrent events and functional restoration.
Neuromuscular and Peripheral Nerve Disorders
Therapeutic development for disorders affecting peripheral motor function.
- Immunoglobulin therapy for chronic inflammatory demyelinating polyneuropathy
- Targeted dopamine modulation in dyskinetic cerebral palsy
- Complement inhibition for multifocal motor neuropathy
Efforts aim to improve strength, mobility, and quality of life.
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