Jesús H. I.
- Country
- Spain
- Department
- 202: Unidad de Gestion Clínica Salud Mental
Research Overview
- A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Tolerability of MRM-3379 in Male Participants with Fragile X Syndrome
- Long‑Term Open‑Label Safety, Tolerability, and Efficacy of Azetukalner (XPF‑010) in Adults with Major Depressive Disorder
- A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy of Azetukalner in Patients with Moderate-to-Severe Major Depressive Disorder
Data & Insights
Has run more than one trial at 18 of 22 partner sites.
Specializations
Oncology
Clinical research activity includes a broad range of solid tumors and hematologic malignancies, with particular emphasis on non-small cell lung cancer, small cell lung cancer, melanoma, breast cancer, colorectal cancer, pancreatic cancer, and head and neck squamous cell carcinoma.
- Targeted therapy in mutation-defined tumors
- Immuno-oncology and checkpoint-based treatment strategies
- Advanced and metastatic cancer
- Adjuvant and neoadjuvant cancer care
Research interests also extend to urothelial carcinoma, ovarian cancer, endometrial cancer, gastric cancer, and multiple myeloma, reflecting sustained involvement in oncology innovation.
Neurology and neuroimmunology
The investigator is involved in studies of epilepsy, multiple sclerosis, amyotrophic lateral sclerosis, myasthenia gravis, and other autoimmune neurologic disorders.
- Focal seizures and generalized tonic-clonic seizures
- Relapsing and progressive multiple sclerosis
- Neuromuscular junction disease
- Neurodegenerative motor disorders
Additional interest includes developmental and epileptic encephalopathies, tuberous sclerosis complex-related epilepsy, and autoimmune encephalitis.
Autoimmune, rheumatologic, and inflammatory disease
Research involvement spans rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, systemic sclerosis, Sjögren’s syndrome, and idiopathic inflammatory myopathy.
- Systemic autoimmune disease
- Inflammatory arthritides
- Connective tissue disease
- Chronic spontaneous urticaria
The clinical portfolio also includes bullous pemphigoid, vasculitis-related renal disease, and immune-mediated neuropathy.
Respiratory and allergy
Therapeutic interests include asthma, allergic rhinitis, allergic rhinoconjunctivitis, atopic dermatitis, and chronic obstructive pulmonary disease.
- Allergen immunotherapy
- Eosinophilic airway disease
- Chronic upper airway inflammation
- Atopic and hypersensitivity disorders
Work in this area also touches peanut allergy, chronic inducible urticaria, and respiratory tract disease associated with inflammatory airway control.
Cardiometabolic, renal, and transplant medicine
Additional clinical interests cover coronary artery disease, heart failure, stroke prevention, type 2 diabetes, obesity, and hypertriglyceridemia, alongside chronic kidney disease and kidney transplant rejection.
- Atherosclerotic cardiovascular disease
- Renal impairment and proteinuric kidney disease
- Metabolic disease
- Transplant-associated complications
The research landscape also includes hemophilia, thrombotic microangiopathy, and infectious complications after transplantation.
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