Jeanine R.
- Country
- The Netherlands
- Department
- Medische Oncologie
Research Overview
- Evaluation of Sotorasib (AMG 510) in Patients with Advanced Solid Tumors Harboring KRAS p.G12C Mutation: A Master Protocol Study
- A Phase I/II Study of AMG 410 Monotherapy and Combination Therapy in Participants with KRAS-Altered Advanced or Metastatic Solid Tumors
- Sotorasib and Combination Therapy Versus Standard Chemotherapy in Treatment-Naïve Patients with KRAS p.G12C-Mutated Metastatic Colorectal Cancer
Data & Insights
Has run more than one trial at 104 of 278 partner sites.
Specializations
Colorectal Cancer Genetics
This investigator specializes in treating colorectal cancer with specific genetic mutations, including studies on BRAF V600E-mutant metastatic colorectal cancer and tumors with KRAS p.G12C mutations. Their work extends to cases with microsatellite instability-high (MSI-H) characteristics.
- Genetic Mutation Analysis
- Targeted Therapy Approaches
- Molecular Profiling
The research encompasses various genetic markers in colorectal cancer and their treatment implications.
Advanced Treatment Strategies
The investigator focuses on developing innovative treatment combinations for colorectal cancer, including immunotherapy approaches and targeted therapeutic agents. Their work includes studies of hepatic arterial infusion pump chemotherapy for liver metastases.
- Combination Therapy Protocols
- Immunotherapy Integration
- Regional Treatment Delivery
These approaches aim to improve outcomes in both localized and metastatic disease settings.
Disease-Specific Focus
The investigator has particular expertise in treating locally advanced rectal cancer and colorectal liver metastases. Their research includes work with resectable colon cancer and various stages of disease progression.
- Stage-Specific Treatments
- Surgical Integration
- Disease Management Strategies
The work encompasses both early-stage and advanced disease scenarios.
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