Jean-Marc L. G.
- Country
- France
- Department
- neurologie
Research Overview
Data & Insights
Has run more than one trial at 0 of 7 partner sites.
Specializations
Neurodegenerative Disorders
Focused on progressive brain disorders that impair cognition and motor function, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis.
- Early‑stage Alzheimer’s clinical trials
- Neuroprotective strategies for Parkinson’s
- Gene‑silencing approaches in ALS
- Biomarker development for disease progression
Research aims to identify disease‑modifying therapies that can alter the natural history of these conditions.
Neuro‑Oncology
Investigates malignant neoplasms of the central nervous system, such as glioblastoma and metastatic brain lesions.
- Targeted molecular inhibitors for glioma
- Immunotherapy for CNS metastases
- Intra‑operative imaging to improve resection
- Radiation‑sparing techniques for brain tumors
The goal is to expand therapeutic options for patients with primary and secondary brain cancers.
Neuro‑Immunology
Explores immune‑mediated conditions affecting the nervous system, including multiple sclerosis, neuromyelitis optica spectrum disorder, and autoimmune encephalitis.
- B‑cell depletion in multiple sclerosis
- Complement inhibition for NMOSD
- Novel biomarkers for autoimmune encephalitis
- Combination immunotherapy regimens
Efforts concentrate on modulating pathogenic immune pathways while preserving neurological function.
Vascular Neurology
Addresses cerebrovascular events such as ischemic stroke, intracerebral hemorrhage, and aneurysmal subarachnoid hemorrhage.
- Thrombolytic and thrombectomy optimization
- Neuroprotective agents post‑stroke
- Management of vasospasm after SAH
- Risk stratification for hemorrhagic transformation
Research seeks to improve acute management and long‑term outcomes for vascular brain injuries.
Neuro‑Infectious Diseases
Targets infections of the nervous system, including herpes simplex encephalitis, HIV‑associated neurocognitive disorder, and opportunistic fungal meningitis.
- Antiviral therapy optimization for encephalitis
- Immune restoration strategies in HIV CNS infection
- Adjunctive antifungal regimens for meningitis
- Diagnostic biomarker discovery for CNS infections
The focus is on enhancing therapeutic efficacy and reducing neurological sequelae of infectious diseases.
Related Investigators
Researchers in similar fields or departments
Want to know more about this investigator?
We can share extended profile information and contact details.
Is something out of date?
Tell us what needs correcting and we'll update this profile.