Janette B.
- Country
- Slovakia
- Department
- Dermatovenerology clinic
Research Overview
- Phase 3 Study on the Safety and Efficacy of Upadacitinib Versus Dupilumab in Pediatric Patients Aged 2-12 with Moderate to Severe Atopic Dermatitis
- Efficacy and Safety Evaluation of Anifrolumab in Refractory Chronic and Subacute Cutaneous Lupus Erythematosus: A Phase III Randomized, Double-Blind, Placebo-Controlled Study
Data & Insights
Has run more than one trial at 13 of 118 partner sites.
Specializations
Dermatology and inflammatory skin disease
Clinical research activity is centered on atopic dermatitis, hidradenitis suppurativa, chronic spontaneous urticaria, and cutaneous lupus erythematosus, with attention to immune-mediated skin inflammation and symptom control.
- Moderate to severe atopic dermatitis
- Hidradenitis suppurativa
- Chronic spontaneous urticaria
- Cutaneous lupus erythematosus
The therapeutic focus includes targeted treatment strategies for persistent dermatologic inflammation and skin barrier disease.
Neuropsychiatry and cognitive disorders
Research involvement extends to psychiatric and neurocognitive conditions, including schizophrenia, major depressive disorder, bipolar I disorder, and Alzheimer’s disease-related psychosis.
- Schizophrenia
- Major depressive disorder
- Bipolar I disorder
- Psychosis associated with Alzheimer’s disease
There is also interest in mild cognitive impairment and depressive syndromes with insomnia, reflecting a broad therapeutic scope in brain and behavior disorders.
Kidney and proteinuric disease
Clinical trial activity includes chronic kidney disease and immune-mediated renal disorders such as IgA nephropathy, focal segmental glomerulosclerosis, and idiopathic immune complex mediated membranoproliferative glomerulonephritis.
- Chronic kidney disease
- IgA nephropathy
- Focal segmental glomerulosclerosis
- Idiopathic immune complex mediated membranoproliferative glomerulonephritis
The therapeutic emphasis is on proteinuria reduction, renal protection, and preservation of kidney function in progressive disease.
Autoimmune, hepatic, and systemic immune conditions
Investigational work also covers broader immune-mediated disorders, including multiple sclerosis, primary biliary cholangitis, non-alcoholic steatohepatitis, and liver cirrhosis.
- Relapsing multiple sclerosis
- Primary biliary cholangitis
- Non-alcoholic steatohepatitis
- Liver cirrhosis
This area includes immune modulation, hepatic disease management, and treatment of chronic inflammatory complications.
Hematology, vascular, and rare disease therapeutics
Additional research interests include chronic myeloid leukemia, relapsed/refractory multiple myeloma, acute ischemic stroke, high-risk transient ischemic attack, and fetal and neonatal alloimmune thrombocytopenia.
- Chronic myeloid leukemia
- Relapsed/refractory multiple myeloma
- Acute ischemic stroke
- Fetal and neonatal alloimmune thrombocytopenia
These studies reflect involvement in oncology, thrombosis prevention, and rare immune and hematologic disorders.
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