Jan M.
- Country
- Czechia
- Department
- III. interní klinika, Kardionefrologické centrum / III. Internal clinic, Cardio Nephrology Center
Research Overview
Data & Insights
Has run more than one trial at 31 of 309 partner sites.
Specializations
Cardiovascular medicine and thrombotic disease
Clinical research activity is strongly centered on cardiovascular disease, with interest in acute myocardial infarction, heart failure, atrial fibrillation, atherosclerotic cardiovascular disease, and cardiogenic shock. The portfolio also includes prevention of recurrent ischemic events and management of high-risk vascular conditions.
- Acute coronary syndromes
- Heart failure and cardiomyopathy
- Atrial fibrillation and stroke prevention
- Atherosclerosis and lipid-related risk
Additional involvement extends to pulmonary hypertension and other cardiovascular complications linked to systemic disease.
Nephrology and immune-mediated kidney disease
The investigator is active in trials focused on chronic kidney disease, IgA nephropathy, focal segmental glomerulosclerosis, proteinuria, and rapidly progressive glomerulonephritis. This includes renal disorders associated with autoimmune and inflammatory conditions.
- IgA nephropathy
- Focal segmental glomerulosclerosis
- Chronic kidney disease
- Glomerulonephritis and proteinuria
Research interests also cover lupus nephritis, anti-GBM disease, and ANCA-associated vasculitis.
Hematology and blood cancers
Clinical trial involvement includes a broad range of hematologic malignancies, particularly multiple myeloma, chronic lymphocytic leukemia, diffuse large B-cell lymphoma, mantle cell lymphoma, and follicular lymphoma. The portfolio reflects sustained interest in relapsed and refractory blood cancers as well as marrow failure disorders.
- Multiple myeloma
- Chronic lymphocytic leukemia
- Diffuse large B-cell lymphoma
- Myelodysplastic syndromes
Additional activity includes acute myeloid leukemia, lymphoma, and immune thrombocytopenia.
Autoimmune, inflammatory, and neurologic disorders
The investigator also contributes to studies in systemic lupus erythematosus, Crohn's disease, ulcerative colitis, atopic dermatitis, and hidradenitis suppurativa. Neurologic involvement includes multiple sclerosis, myasthenia gravis, and neuropathy.
- Systemic lupus erythematosus
- Multiple sclerosis
- Inflammatory bowel disease
- Autoimmune skin disease
Research activity further spans uveitis, thyroid eye disease, and other immune-driven organ disorders.
Metabolic, endocrine, and organ-specific disease
Trial participation includes obesity, type 2 diabetes mellitus, hypertriglyceridemia, non-alcoholic steatohepatitis, and liver cirrhosis. The investigator also has interest in inherited and protein-folding disorders such as transthyretin amyloid cardiomyopathy and Fabry disease.
- Obesity and type 2 diabetes
- Metabolic dysfunction-associated steatotic liver disease
- Transthyretin amyloid cardiomyopathy
- Fabry disease
Additional areas include retinal disease, glaucoma, and macular degeneration.
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