Jan H.
- Country
- Czechia
- Department
- Opthalmology
Research Overview
- A Randomized, Double-masked Study Comparing the Efficacy and Safety of AVT29 Versus High-Dose Aflibercept in Participants with Diabetic Macular Edema
- Randomized, Double-Masked, Multicenter Phase 2/3 Trial of Intravitreal MK-8748 Versus Aflibercept in Patients with Neovascular Age‑Related Macular Degeneration
- Evaluation of Efficacy and Safety of Intravitreal EYE103 Versus Ranibizumab in Diabetic Macular Edema: A Randomized, Double-Masked, Multi-Center Study
Data & Insights
Has run more than one trial at 84 of 173 partner sites.
Specializations
Ophthalmology and retinal disease
Clinical research includes diabetic macular edema, age-related macular degeneration, geographic atrophy, retinal vein occlusion, ocular hypertension, and open-angle glaucoma, with attention to vision preservation and retinal vascular disorders.
- Diabetic macular edema
- Neovascular age-related macular degeneration
- Geographic atrophy
- Macular edema secondary to retinal vein occlusion
- Open-angle glaucoma
Work in this area also extends to diabetic retinopathy assessment and other sight-threatening complications of metabolic disease.
Hematologic malignancies
Research activity spans lymphoma, multiple myeloma, chronic lymphocytic leukemia, acute myeloid leukemia, and related myelodysplastic syndromes, reflecting a strong focus on blood cancers and relapsed disease settings.
- Follicular lymphoma
- Diffuse large B-cell lymphoma
- Chronic lymphocytic leukemia
- Multiple myeloma
- Myelodysplastic syndromes
Interest also includes classical Hodgkin lymphoma, mantle cell lymphoma, and marginal zone lymphoma.
Solid tumors and oncology
Clinical trial involvement covers breast cancer, renal cell carcinoma, prostate cancer, ovarian cancer, cervical cancer, head and neck squamous cell carcinoma, and melanoma, with additional interest in urothelial carcinoma and non-small cell lung cancer.
- Breast cancer
- Renal cell carcinoma
- Prostate cancer
- Ovarian cancer
- Melanoma
Research also includes high-risk non-muscle-invasive bladder cancer and other advanced malignancies requiring systemic treatment strategies.
Immune-mediated, inflammatory, and dermatologic disorders
The investigator is active in studies of ulcerative colitis, Crohn's disease, hidradenitis suppurativa, atopic dermatitis, plaque psoriasis, and chronic spontaneous urticaria, alongside other immune-driven conditions.
- Ulcerative colitis
- Crohn's disease
- Hidradenitis suppurativa
- Atopic dermatitis
- Plaque psoriasis
Additional areas include immune thrombocytopenia, IgA nephropathy, and systemic mastocytosis.
Cardiovascular, metabolic, and neurologic disease
Research interests include myocardial infarction, atrial fibrillation, heart failure, stroke prevention, deep vein thrombosis, and pulmonary hypertension, together with metabolic and neurologic conditions such as type 1 diabetes and multiple sclerosis.
- Myocardial infarction
- Atrial fibrillation
- Heart failure
- Type 1 diabetes
- Multiple sclerosis
Work in this domain also covers anticoagulation reversal, acute ischemic stroke, and obesity.
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