j. Z.
- Country
- The Netherlands
- Department
- Hematology
Research Overview
Data & Insights
Has run more than one trial at 0 of 31 partner sites.
Specializations
Acute Myeloid Leukemia and Related Myeloid Disorders
The investigator concentrates on therapeutic strategies for Acute Myeloid Leukemia and associated myeloid neoplasms, addressing disease biology, resistance mechanisms, and post‑remission management.
- Acute Myeloid Leukemia
- Myelodysplastic Syndromes
- Blastic Plasmacytoid Dendritic Cell Neoplasia
- IDH‑mutated AML
- Therapy‑related myeloid neoplasms
Research integrates novel agents with established chemotherapy to improve survival outcomes.
Lymphoid Malignancies
Focused on curative and maintenance approaches for malignant disorders of the lymphoid system, including both B‑cell and T‑cell origins.
- Diffuse Large B‑Cell Lymphoma
- Chronic Lymphocytic Leukemia
- Mantle Cell Lymphoma
- Hodgkin Lymphoma
- Peripheral T‑cell Lymphoma
Efforts emphasize targeted therapies and immunomodulatory regimens.
Plasma Cell Dyscrasias
Investigations target disorders of plasma cell proliferation, ranging from premalignant conditions to overt multiple myeloma.
- Multiple Myeloma
- Monoclonal Gammopathy of Undetermined Significance
- Smoldering Myeloma
- Light‑chain Amyloidosis
- Plasma Cell Leukemia
Therapeutic development includes novel immunotherapies and combination regimens.
Myeloproliferative Neoplasms
The investigator explores disease‑modifying treatments for clonal proliferative disorders of the hematopoietic stem cell.
- Primary Myelofibrosis
- Polycythemia Vera
- Essential Thrombocythemia
- Chronic Myeloid Leukemia (Chronic Phase)
- JAK‑inhibitor refractory disease
Research aims to reduce splenomegaly, symptom burden, and disease progression.
Hemostasis and Bleeding Disorders
Clinical work includes management of inherited and acquired coagulopathies, with emphasis on novel replacement and prophylactic therapies.
- Hemophilia A
- Acquired Angioedema
- Hereditary Angioedema
- Platelet function disorders
- Anticoagulant‑related bleeding
Focus is on improving quality of life and reducing bleeding episodes.
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