J.J. H.
- Country
- The Netherlands
- Department
- Surgery
Research Overview
Data & Insights
Has run more than one trial at 0 of 12 partner sites.
Specializations
Oncology – Solid Tumors
The investigator’s work spans a broad spectrum of malignant neoplasms, emphasizing advanced disease stages and innovative systemic regimens.
- Advanced non‑small cell lung cancer
- HER2‑positive esophageal adenocarcinoma
- Metastatic castration‑resistant prostate cancer
- Triple‑negative breast cancer
- Muscle‑invasive urothelial carcinoma
Focus includes targeted agents, antibody‑drug conjugates, and combination immunotherapy strategies.
Cardiovascular & Vascular Medicine
Research addresses arterial disease, rhythm disorders, and prevention of cardiovascular events across high‑risk populations.
- Atherosclerotic cardiovascular disease
- Peripheral arterial disease
- Atrial fibrillation
- Major adverse cardiovascular events
- Antiplatelet therapy in colon cancer survivors
Efforts target novel anticoagulants, lipid‑lowering therapies, and long‑term outcome optimization.
Metabolic & Renal Disease
Investigation centers on metabolic dysfunction, renal impairment, and strategies to mitigate organ damage.
- Type 2 diabetes
- Chronic kidney disease
- Albuminuria reduction
- Obesity management
- Renal outcomes with SGLT2 inhibition
Key interests include combination therapy with GLP‑1 receptor agonists and mineralocorticoid receptor antagonists.
Infectious & Surgical Complications
Clinical focus includes prevention and treatment of infections and pain following major abdominal and thoracic procedures.
- Complicated appendicitis
- Post‑surgical neuropathic pain
- Peri‑operative antimicrobial decontamination
- Community‑acquired pneumonia
- Esophagectomy infection prevention
Studies evaluate short‑course high‑dose antibiotics and selective decontamination protocols.
Rheumatology & Autoimmune Inflammation
Research addresses inflammatory rheumatic conditions and biologic interventions aimed at disease remission.
- Polymyalgia rheumatica
- Giant cell arteritis
- IL‑17 inhibition in inflammatory diseases
- Glucocorticoid tapering strategies
- Biologic therapy safety
Efforts prioritize sustained remission with reduced corticosteroid exposure.
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