Menuhin L.
- Country
- The Netherlands
- Department
- Urologie
Research Overview
- Evaluation of Aspirin Omission on Bleeding and Ischemic Outcomes in Non-ST-Segment Elevation Acute Coronary Syndrome Patients
- Evaluation of Flortaucipir (18F) PET Imaging for Diagnostic Enhancement in Patients with Mild Cognitive Impairment and Dementia
- Evaluation of Hepatic Arterial Infusion of Floxuridine with Systemic Therapy in Unresectable Colorectal Liver Metastases: A Randomized Controlled Trial
Data & Insights
Has run more than one trial at 89 of 263 partner sites.
Specializations
Breast cancer and endocrine oncology
Clinical research activity includes treatment strategies for advanced breast cancer, HER2-positive breast cancer, HER2-low breast cancer, triple-negative breast cancer, and hormone receptor-positive disease, with interest in endocrine therapy, CDK4/6 inhibition, and antibody-drug conjugates.
- Advanced and metastatic breast cancer
- HER2-positive and HER2-low disease
- Triple-negative breast cancer
- Endocrine-based treatment sequencing
Work in this area also extends to recurrence prevention, biomarker-informed treatment selection, and optimization of systemic therapy in early and advanced settings.
Gastrointestinal oncology and colorectal surgery
The investigator is involved in studies across rectal cancer, colorectal cancer, pancreatic cancer, gastric cancer, and esophagogastric cancer, with emphasis on organ preservation, perioperative treatment, and locally advanced disease.
- Early and locally advanced rectal cancer
- Colorectal liver metastases
- Pancreatic cancer
- Gastric and gastroesophageal junction cancer
Research interests include ctDNA-guided treatment, chemoradiotherapy, surgical decision-making, and approaches that support rectal preservation and improved resectability.
Haematologic malignancies and cellular therapy
Clinical trial involvement covers acute myeloid leukemia, chronic lymphocytic leukemia, small lymphocytic lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, marginal zone lymphoma, mantle cell lymphoma, and multiple myeloma.
- Leukemia and lymphoma
- Relapsed and refractory hematologic disease
- Myelodysplastic syndrome
- Myeloma and precursor plasma cell disorders
Therapeutic focus includes venetoclax-based combinations, immunotherapy, B-cell targeted treatment, and novel approaches for high-risk or treatment-resistant blood cancers.
Cardiovascular medicine, heart failure, and kidney disease
Research activity includes atherosclerotic cardiovascular disease, myocardial infarction, atrial fibrillation, cardiogenic shock, heart failure, chronic kidney disease, and prevention of acute kidney injury.
- Secondary prevention of cardiovascular events
- Heart failure with impaired renal function
- Post-infarction cardiac recovery
- Thromboembolic and antithrombotic care
The portfolio also includes lipid-lowering strategies, renal-protective therapy, and interventions for patients with overlapping cardiac and renal risk.
Thoracic oncology, uro-oncology, and immune-mediated disease
The investigator is engaged in studies of non-small cell lung cancer, small cell lung cancer, urothelial cancer, prostate cancer, melanoma, and selected immune-mediated inflammatory diseases.
- Lung cancer and metastatic solid tumors
- Urothelial carcinoma and prostate cancer
- Melanoma and immunotherapy-based care
- Rheumatoid arthritis and pulmonary sarcoidosis
Therapeutic interests include checkpoint inhibition, targeted oncology, and treatment strategies for severe asthma, rheumatoid arthritis, and pulmonary sarcoidosis.
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