J.A.A.C. H.
- Country
- The Netherlands
- Department
- Experimental Medicine
Research Overview
- Evaluation of the Analgesic Efficacy of Lu AG06474 in Healthy Adult Subjects with Induced Pain
- Evaluation of Cannabidiol on Central Nervous System Function and Cortical Excitability in Healthy Males: A Randomized, Double-Blind, Placebo-Controlled Crossover Study
- A Study on the Pharmacokinetic Interactions of Cannabidiol, Amitriptyline, and Tramadol in Neurological Assessments
Data & Insights
Has run more than one trial at 1 of 1 partner site.
Specializations
Neuropathic Pain & Analgesia
The investigator studies chronic neuropathic pain and evaluates novel analgesic mechanisms.
- Diabetic peripheral neuropathy
- Opioid‑induced respiratory depression
- Acute and chronic neuropathic pain
- Opioid use disorder
- Pain modulation in healthy volunteers
Therapeutic focus includes targeting sensory pathways to improve pain relief.
Dermatological Inflammatory Disorders
Research efforts concentrate on atopic dermatitis and urticaria phenotypes.
- Chronic spontaneous urticaria
- Chronic inducible urticaria
- Plaque psoriasis
- Eczema
- Atopic eczema
Work aims to elucidate immune pathways driving skin inflammation.
Neurodegenerative & Neuroinflammatory Diseases
Investigator involvement spans neurodegenerative disorders and related inflammatory processes.
- Parkinson's disease
- Frontotemporal dementia
- Amyotrophic lateral sclerosis
- Multiple sclerosis (progressive)
- Neuroinflammatory conditions
Focus is on disease‑modifying strategies and biomarkers of neuro‑inflammation.
Autoimmune & Immuno‑oncology Assessments
Studies target autoimmune diseases and emerging immuno‑oncology biomarkers.
- Systemic lupus erythematosus
- Rheumatoid arthritis
- Discoid lupus erythematosus
- Immune system diseases
- Immuno‑oncology assessments
Efforts aim to translate immune modulation into therapeutic benefit.
Movement Disorders & Parkinsonian Syndromes
Dedicated to understanding movement disorders with a focus on genetic subtypes.
- Parkinson’s disease with GBA1 mutation
- Spinal muscular atrophy
- Facioscapulohumeral muscular dystrophy
- Hidradenitis
- Hyperexcitability nerve disorder
Therapeutic aims include disease‑modifying interventions and symptom management.
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