Clinical Research
person

Ivan F.

Country
Italy
Department
Radiotherapy

Research Overview

assignment
1
Clinical Trials ·
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1
Research Sites

Data & Insights

medical_services
Primary Speciality
Main therapeutic area

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Return Partnerships
Recurring site collaborations
0
Sites with multiple studies

Has run more than one trial at 0 of 14 partner sites.

Specializations

Molecularly Guided Colorectal Cancer Treatment

Investigates RAS/BRAF mutation‑driven metastatic colorectal cancer using biomarker‑selected therapeutic regimens.

  • Intermittent Panitumumab plus FOLFIRI
  • Bevacizumab versus Cetuximab combinations
  • Valproic acid with anti‑angiogenic therapy
  • Ir​inotecan plus Cetuximab superiority
  • Continuation of Cetuximab beyond progression

Emphasizes predictive biomarker assessment and resistance monitoring.

Prostate Cancer Radiotherapy and Hormonal Integration

Applies ultra‑hypofractionated radiotherapy combined with oral relugolix for intermediate risk disease and evaluates androgen deprivation therapy adjuncts.

  • Ultra‑hypofractionated radiotherapy with Relugolix
  • Prostate SBRT with or without ADT
  • Biochemical complete response assessment

Targets improvement of quality of life and biochemical disease‑free survival.

Locally Advanced Rectal Cancer Neoadjuvant Therapy

Explores multimodal neoadjuvant protocols integrating aspirin, metformin and chemoradiation for downstaging.

  • Aspirin and Metformin combined with induction chemotherapy
  • Preoperative chemoradiation optimization
  • Good pathological response endpoints

Seeks enhanced tumor regression prior to surgery.

Targeted Anti‑angiogenic and EGFR Strategies

Focuses on anti‑VEGF and EGFR inhibition in colorectal malignancies, assessing progression‑free outcomes.

  • Bevacizumab plus chemotherapy versus Cetuximab plus chemotherapy
  • Ir​inotecan plus Cetuximab versus trifluridine/tipiracil plus Bevacizumab
  • Continuation of Cetuximab beyond first‑line progression

Analyzes comparative efficacy across molecular subgroups.

Advanced Radiotherapy Modalities

Utilizes stereotactic body radiation therapy (SBRT) and integrates systemic agents to augment local control.

  • SBRT with ADT versus SBRT alone
  • Imaging‑guided response assessment
  • Integration of systemic therapy with radiation

Aims to refine dose delivery and synergistic treatment effects.

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