Ismael A. G.
- Country
- Spain
- Department
- Pneumology
Research Overview
- A Phase 2b Dose-Ranging Study of Oral KT-621 in Adults with Uncontrolled Moderate to Severe Eosinophilic Asthma
- Phase 3b/4 Randomized Double‑Blind Study of Depemokimab 100 mg SC Q26 weeks vs Placebo on Exacerbations and Lung‑Function Decline in Adults/Adolescents with Type 2 Asthma
- Efficacy and Safety Evaluation of Atuliflapon in Adults with Moderate-to-Severe Uncontrolled Asthma: A Phase 2a Randomized, Double-Blind, Placebo-Controlled Trial
Data & Insights
Has run more than one trial at 179 of 542 partner sites.
Specializations
Respiratory Medicine and Airway Inflammation
Clinical research activity in asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and other interstitial lung diseases is a central area of interest, with attention to both uncontrolled disease and eosinophilic airway inflammation.
- Severe asthma
- Progressive pulmonary fibrosis
- Pulmonary sarcoidosis
- Pulmonary tuberculosis
Additional involvement includes eosinophilic esophagitis and allergic rhinoconjunctivitis, reflecting a broad focus on inflammatory disorders affecting the respiratory tract and related mucosal disease.
Hematologic Malignancies
The investigator is actively involved in trials for chronic lymphocytic leukemia, small lymphocytic lymphoma, follicular lymphoma, mantle cell lymphoma, and diffuse large B-cell lymphoma, together with other lymphoid and myeloid cancers.
- Multiple myeloma
- Acute myeloid leukemia
- Non-Hodgkin lymphoma
- Chronic myeloid leukemia
This research landscape also includes relapsed and refractory disease settings, supporting therapeutic development across B-cell malignancies and plasma cell disorders.
Autoimmune and Inflammatory Disorders
Research interests extend to systemic and skin-mediated immune diseases such as atopic dermatitis, plaque psoriasis, psoriatic arthritis, systemic lupus erythematosus, and cutaneous lupus erythematosus.
- Idiopathic inflammatory myopathies
- Sjögren’s syndrome
- Hidradenitis suppurativa
- Ulcerative pyoderma gangrenosum
There is also participation in studies of eosinophilic disorders and hypereosinophilic syndrome, indicating sustained engagement with immune-mediated inflammation across multiple organ systems.
Infectious Diseases and Antiviral Therapy
Clinical trial activity includes HIV infection, hepatitis B, COVID-19, and severe community-acquired bacterial pneumonia, with a clear therapeutic emphasis on chronic viral management and acute infectious disease care.
- Antiretroviral therapy
- HIV-1 infection
- Chronic hepatitis B
- Smear-positive pulmonary tuberculosis
These studies also connect to metabolic liver disease in people with HIV, broadening the infectious disease focus to long-term comorbidity management.
Allergy, Dermatology, and Immune-Mediated Comorbidity
Additional research spans alopecia areata, vitiligo, gout with hyperuricemia, immunoglobulin A nephropathy, and primary immune thrombocytopenia, showing involvement in diverse immune-driven conditions.
- Atopic dermatitis
- Allergic rhinoconjunctivitis
- Nonsegmental vitiligo
- Primary Sjögren’s disease
Work in these areas reflects a therapeutic interest in chronic inflammatory disease control, symptom reduction, and targeted immune modulation.
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