Isik S. J.
- Country
- Denmark
- Department
- Infektionsmedicinsk afdeling
Research Overview
- Efficacy and Safety of AZD5148 for the Prevention of Recurrent Clostridioides difficile Infection in Adults: A Phase IIb, Randomized, Placebo-Controlled Study
- Safety and Efficacy of Anti-Hepatitis D Virus Antibodies in Patients with Chronic Hepatitis D Infection: The SAMBA-D Study
- Randomized, Double‑Blind, Placebo‑Controlled Trial of Long‑Acting bNAbs 10‑1074‑LS and 3BNC117‑LS with Low‑Dose Nivolumab for Durable HIV‑1 Remission during ART Interruption
Data & Insights
Has run more than one trial at 55 of 206 partner sites.
Specializations
Infectious Diseases and Mycobacterial Lung Infection
Clinical research activity includes treatment-focused work in infektionsmedicinsk afdeling with emphasis on nontuberculous mycobacterial lung infection, including Mycobacterium avium complex, as well as broader management of bacterial infection, fungal infection, and sepsis.
- Nontuberculous mycobacterial lung infection
- Mycobacterium avium complex
- Sepsis and bacteremia
- Chronic hepatitis B and chronic hepatitis D
Additional therapeutic interest extends to HIV infection, COVID-19, and hospital-based management of complicated infectious syndromes.
Cardiovascular Medicine and Thromboembolic Disease
The investigator is involved in clinical research on atherosclerotic cardiovascular disease, acute coronary syndrome, myocardial infarction, atrial fibrillation, heart failure, and cardiac arrest, with a strong focus on prevention and acute care.
- Acute coronary syndrome and myocardial infarction
- Atrial fibrillation and stroke prevention
- Heart failure and cardiovascular risk reduction
- Pulmonary embolism and cardiac arrest
Therapeutic activity also includes dyslipidemia, hypertension, and obesity in relation to cardiovascular risk modification.
Autoimmune, Inflammatory, and Allergic Disorders
Research interests cover immune-mediated diseases such as Crohn’s disease, ulcerative colitis, psoriatic arthritis, systemic lupus erythematosus, Sjögren’s syndrome, and vasculitis, alongside asthma and chronic urticaria.
- Crohn’s disease and ulcerative colitis
- Rheumatoid arthritis and psoriatic arthritis
- Systemic lupus erythematosus and vasculitis
- Asthma, urticaria, and atopic dermatitis
Additional therapeutic areas include myasthenia gravis, chronic inflammatory demyelinating polyneuropathy, and sarcoidosis.
Oncology and Hematologic Malignancies
The investigator is active in clinical trials across solid tumors and blood cancers, including breast cancer, colorectal cancer, lung cancer, ovarian cancer, bladder cancer, and prostate cancer.
- Acute lymphoblastic leukemia and acute myeloid leukemia
- Multiple myeloma and lymphoma
- Breast cancer and ovarian cancer
- Glioblastoma and other central nervous system tumors
Therapeutic involvement also spans melanoma, pancreatic cancer, endometrial cancer, and gastrointestinal malignancies.
Neurology, Renal Disease, and Metabolic Disorders
Clinical research activity includes multiple sclerosis, migraine, epilepsy, and stroke, together with kidney-focused work in chronic kidney disease, IgA nephropathy, and proteinuria.
- Multiple sclerosis and epilepsy
- Stroke and intracerebral haemorrhage
- Chronic kidney disease and IgA nephropathy
- Type 1 diabetes and type 2 diabetes
Additional therapeutic interests include liver disease, osteoporosis, and amyloidosis.
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