Isabelle S.
- Country
- Belgium
- Department
- Pediatric Gastroenterology and Hepatology
Research Overview
- A Phase 3, Multi-Center Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Risankizumab with Open-Label Induction, Randomized Double-Blind Maintenance, and Long-Term Extension Periods in Pediatric Subjects (2 to < 18 Years of Age) with Moderately to Severely Active Crohn's Disease
- Open-Label Induction and Maintenance Study of Oral Tofacitinib in Pediatric Patients with Moderately to Severely Active Ulcerative Colitis
- Evaluation of Upadacitinib Efficacy, Safety, and Pharmacokinetics in Pediatric Patients with Moderate to Severe Crohn's Disease: A Phase 3 Multicenter Study
Data & Insights
Has run more than one trial at 37 of 91 partner sites.
Specializations
Inflammatory Bowel Disease and Pediatric Gastroenterology
The investigator is involved in clinical research focused on Crohn’s disease, ulcerative colitis, and broader inflammatory bowel diseases in children and adolescents, with interest in therapeutic strategies that address intestinal inflammation and disease control.
- Moderately to severely active Crohn’s disease
- Moderately to severely active ulcerative colitis
- Pediatric inflammatory bowel disease
Clinical activity also includes treatment approaches aimed at maintaining remission and improving symptom control in pediatric digestive disease.
Immune-Mediated and Inflammatory Disorders
Research interests extend to immune-driven conditions involving the skin, joints, and systemic inflammation, including psoriasis, atopic dermatitis, hidradenitis suppurativa, and juvenile idiopathic arthritis.
- Moderate to severe plaque psoriasis
- Atopic dermatitis
- Hidradenitis suppurativa
Therapeutic involvement also covers chronic pruritic and inflammatory skin disease, reflecting a strong interest in immune modulation.
Pediatric Hepatology and Cholestatic Disease
The investigator contributes to studies in pediatric liver disease, with emphasis on primary biliary cholangitis, primary sclerosing cholangitis, and related cholestatic symptoms such as pruritus.
- Primary biliary cholangitis
- Primary sclerosing cholangitis
- Cholestatic pruritus
This area reflects interest in therapies targeting liver-related inflammation and symptom burden in chronic pediatric and adolescent care.
Pediatric Kidney Disease and Proteinuric Disorders
Clinical research activity includes renal conditions such as chronic kidney disease, proteinuria, and APOL1-mediated proteinuric kidney disease, with attention to disorders affecting renal function in younger patients.
- Chronic kidney disease
- Proteinuric kidney disease
- APOL1-mediated proteinuric kidney disease
Interest also includes inherited and immune-related renal disorders that require targeted therapeutic management.
Pediatric Immunotherapy and Transplant-Related Care
The investigator is involved in research on immune-based treatment options for pediatric patients with complex inflammatory and post-transplant conditions, including acute graft-versus-host disease, chronic graft-versus-host disease, and cytomegalovirus infection after transplant.
- Acute graft-versus-host disease
- Chronic graft-versus-host disease
- Cytomegalovirus infection
Therapeutic interest also includes broader pediatric immune regulation in settings where inflammation and infection intersect.
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