Irene V. D. H. B.
- Country
- The Netherlands
- Department
- Rheumatology
Research Overview
- Effect of Upadacitinib on the Frequency of Acute Recurrent Anterior Uveitis in Patients With Axial Spondyloarthritis: A Real-World Study
- Evaluation of Filgotinib on Cardiac Function, Myocardial Inflammation, and Coronary Plaque Morphology in Rheumatoid Arthritis Patients Without Cardiovascular History
Data & Insights
Has run more than one trial at 1 of 15 partner sites.
Specializations
Inflammatory Bowel Disease
Clinical research activity in ulcerative colitis and Crohn’s disease, with attention to treatment options for active disease and long-term disease control. The therapeutic focus also includes broader inflammatory bowel disease management in both adult and paediatric settings.
- Ulcerative colitis
- Crohn’s disease
- Paediatric inflammatory bowel disease
Work in this area reflects interest in improving gastrointestinal inflammation control and advancing targeted therapies for chronic intestinal disease.
Rheumatology and Autoimmune Disease
Investigator involvement extends to rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis, and Sjögren’s syndrome, alongside other autoimmune disorders and inflammatory-mediated immune diseases. The therapeutic landscape also includes systemic sclerosis and related joint and connective tissue conditions.
- Rheumatoid arthritis
- Axial spondyloarthritis
- Psoriatic arthritis
This area connects immune modulation with musculoskeletal disease control and the treatment of chronic systemic inflammation.
Cardiovascular Medicine
Research interests include atherosclerotic cardiovascular disease, coronary artery disease, heart failure, hypertension, and acute myocardial infarction. The portfolio also covers pulmonary embolism, atrial fibrillation, and vascular risk reduction, with emphasis on cardiometabolic disease and thrombotic complications.
- Atherosclerotic cardiovascular disease
- Heart failure
- Acute myocardial infarction
These topics highlight a strong therapeutic interest in reducing cardiovascular events and improving outcomes in high-risk vascular disease.
Renal and Proteinuric Disorders
Clinical trial involvement includes IgA nephropathy, focal segmental glomerulosclerosis, Alport syndrome, primary membranous nephropathy, and other proteinuric glomerular diseases. The scope also reaches chronic kidney disease and immune-mediated renal injury.
- IgA nephropathy
- Focal segmental glomerulosclerosis
- Primary membranous nephropathy
Interest in this domain centres on kidney preservation, reduction of proteinuria, and therapies for progressive glomerular disease.
Immune-Mediated and Systemic Inflammatory Conditions
The investigator also engages with primary biliary cholangitis, immune thrombocytopenia, autoimmune hemolytic anemia, hemophilia A, and other immune-related conditions. Additional activity includes inflammation-driven disorders and selected rare disease settings where immune dysregulation plays a central role.
- Primary biliary cholangitis
- Immune thrombocytopenia
- Autoimmune hemolytic anemia
This field reflects therapeutic interest in immune-targeted interventions across chronic autoimmune and inflammatory disease.
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