Ioana Raluca M.
- Country
- Romania
- Department
- Neurology Department
Research Overview
- A Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy and Safety of Clemizole Hydrochloride as Adjunctive Therapy in Patients with Lennox-Gastaut Syndrome
- Evaluation of the Safety and Tolerability of BHV-7000 in Adults with Refractory Focal Onset Epilepsy: A Phase 2 Multicenter Study
- Efficacy and Safety Evaluation of BHV-7000 in Adults with Refractory Focal Onset Epilepsy: A Phase 2/3 Randomized, Double-Blind, Placebo-Controlled Study
Data & Insights
Has run more than one trial at 78 of 157 partner sites.
Specializations
Cardiovascular and Metabolic Medicine
The investigator concentrates on atherosclerotic cardiovascular disease, targeting lipid abnormalities such as elevated lipoprotein(a), and managing heart failure phenotypes including reduced and preserved ejection fraction, while also addressing hypertension and type 2 diabetes as contributors to cardiovascular risk.
- Major adverse cardiovascular events
- Lipid‑lowering therapies
- Heart failure with systemic inflammation
Research aims to integrate novel agents with standard care to lower cardiovascular morbidity and mortality.
Oncology – Lung Cancer and Hematologic Malignancies
Clinical work includes advanced non‑small cell lung cancer and related thoracic tumors, as well as aggressive blood cancers such as large B‑cell lymphoma, multiple myeloma, and acute myeloid leukemia, focusing on targeted and immunotherapeutic strategies.
- PD‑L1–directed therapies
- KRAS‑mutated tumor pathways
- Combination chemo‑immunotherapy regimens
The aim is to improve progression‑free and overall survival in high‑risk oncology populations.
Neurology – Epilepsy and Neurodegenerative Disorders
Investigation centers on treatment‑resistant seizure disorders, including refractory focal onset epilepsy and Lennox‑Gastaut syndrome, alongside disease‑modifying approaches for multiple sclerosis.
- Seizure frequency reduction
- Neuroinflammation modulation
- Long‑term disability outcomes
Efforts aim to deliver durable control of epileptic activity and slow neurodegeneration.
Hematology – Leukemia, Lymphoma, and Immune‑Mediated Conditions
The portfolio includes rare hematologic diseases such as chronic lymphocytic leukemia, acute lymphoblastic leukemia, and complement‑mediated disorders like paroxysmal nocturnal hemoglobinuria, with particular attention to hypogammaglobulinemia‑related infection risk.
- Targeted kinase inhibitors
- Immune‑modulating monoclonal antibodies
- Cellular therapies for refractory disease
Research strives to enhance remission rates and mitigate treatment‑related complications.
Gastroenterology – Inflammatory Bowel Disease and Viral Hepatitis
Active investigation of chronic intestinal inflammation encompasses ulcerative colitis and Crohn’s disease, while also addressing viral liver pathology such as chronic hepatitis D infection.
- Biologic therapy optimization
- Endoscopic remission endpoints
- Antiviral regimen efficacy
The focus is on achieving sustained mucosal healing and viral suppression.
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