LI V. D. B.
- Country
- The Netherlands
- Department
- Rotterdams Oogheelkundig Instituut
Research Overview
- Safety and Efficacy of Subretinal Administration of AAVB-039 in Participants with Stargardt Disease (STGD1): A Phase 1/2 Open-Label, Multicenter Study
- Evaluation of Ultevursen Efficacy, Safety, and Tolerability in Retinitis Pigmentosa Patients with USH2A Exon 13 Mutations: A Two-Year Randomized, Sham-Controlled Study
- Evaluation of Ultevursen Efficacy, Safety, and Tolerability in Retinitis Pigmentosa Patients with USH2A Exon 13 Mutations: A Double-Masked, Randomized, Sham-Controlled Trial
Data & Insights
Has run more than one trial at 9 of 11 partner sites.
Specializations
Retinal Degeneration and Age-related Macular Degeneration
Clinical research is centered on advanced retinal disease, including geographic atrophy, neovascular age-related macular degeneration, and exudative AMD, with interest in preserving visual function and limiting progressive macular damage.
- Geographic atrophy
- Wet AMD
- Submacular haemorrhage
Work in this area also extends to therapies aimed at slowing lesion expansion and improving outcomes in complex macular disease.
Inherited Retinal Disorders
The investigator is involved in studies of retinitis pigmentosa and Stargardt disease, reflecting a focus on inherited retinal degeneration and long-term visual preservation in rare ophthalmic conditions.
- Retinitis pigmentosa
- Stargardt disease
- Genetic retinal dystrophies
This therapeutic domain includes disease-modifying approaches for patients with progressive photoreceptor loss.
Inflammatory and Fluid-related Macular Disease
Clinical interests include uveitic macular edema and central serous chorioretinopathy, with attention to retinal fluid control, macular structure, and visual recovery in inflammatory and chorioretinal disorders.
- Uveitic macular edema
- Central serous chorioretinopathy
- Retinal fluid accumulation
These studies address both chronic edema and serous retinal detachment in sight-threatening disease.
Corneal Surface Repair and Ocular Adnexal Conditions
Research activity also covers persistent corneal epithelial defect and acquired blepharoptosis, indicating involvement in corneal healing and eyelid disorders that affect ocular surface integrity and visual comfort.
- Persistent corneal epithelial defect
- Acquired blepharoptosis
- Ocular surface healing
These therapeutic areas include interventions for epithelial restoration and functional eyelid improvement.
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