IBRAHIM N.
- Country
- France
- Department
- Oncology
Research Overview
- Phase III Multicentric Study on Chemotherapy Efficacy in Stage III Colorectal Cancer with Positive ctDNA Post-Surgery Using Irinotecan and Drug Combination
- Evaluation of Circulating Tumor DNA-Guided Adjuvant Therapy with Fluorouracil, Folinic Acid, and Oxaliplatin in Stage II Colon Carcinoma
- Neoadjuvant Dostarlimab and Short-Course Radiotherapy in Microsatellite Unstable or Mismatch Repair-Deficient Locally Advanced Rectal Cancer
Data & Insights
Has run more than one trial at 92 of 262 partner sites.
Specializations
Oncology and Solid Tumor Care
Oncology is a central area of interest, with clinical activity spanning advanced and recurrent malignancies across the lung, breast, gastric, esophageal, gastroesophageal junction, urothelial, colon, and rectal cancer settings.
- Advanced non-small cell lung cancer
- Breast cancer with ctDNA-positive relapse risk
- Metastatic gastric and upper gastrointestinal cancer
- Colorectal cancer and locally advanced rectal cancer
Clinical research also includes treatment strategies for HER2-negative disease and ctDNA-guided management in gastrointestinal and breast oncology.
Neuroinflammation and Neurological Disease
Work in neurology includes therapeutic investigation in multiple sclerosis and Alzheimer's disease, reflecting interest in immune-mediated and neurodegenerative disorders.
- Relapsing forms of multiple sclerosis
- Moderate to severe plaque psoriasis
- Early to moderate Alzheimer's disease dementia
- Brain lesion activity
The therapeutic landscape includes agents aimed at reducing inflammatory activity and preserving cognitive and neurological function.
Immune-Mediated and Inflammatory Disorders
Clinical involvement extends to immune-mediated disease and chronic inflammatory conditions, particularly psoriasis and multiple sclerosis, where immune modulation is a key therapeutic focus.
- Moderate to severe plaque psoriasis
- Relapsing multiple sclerosis
- Immune pathway modulation
- Inflammatory disease control
These areas align with interest in targeted therapies for chronic immune dysregulation and tissue-specific inflammatory disease.
Critical Care, Sepsis, and Acute Organ Dysfunction
Another major focus is critical care medicine, particularly septic shock, tachycardia, and acute kidney injury in severely ill hospitalized patients.
- Septic shock
- Hypercontractility and hemodynamic instability
- Major adverse kidney events
- Intensive care supportive treatment
Research activity also touches on cardiovascular stress responses and organ protection in the setting of severe infection.
Cardiovascular and Cerebrovascular Prevention
Clinical interests include cardiovascular disease and cerebrovascular disease, with attention to secondary prevention after vascular events and ischemic injury.
- Stroke and transient ischemic attack
- Myocardial infarction
- Atherosclerosis and coronary syndrome
- Cerebral infarction
The therapeutic scope includes strategies aimed at reducing recurrent vascular events and improving long-term vascular outcomes.
Related Investigators
Researchers in similar fields or departments
Want to know more about this investigator?
We can share extended profile information and contact details.
Is something out of date?
Tell us what needs correcting and we'll update this profile.