Iara Karlla D. S. S.
- Country
- Spain
- Department
- Nephrology
Research Overview
- Phase I/IIa Multicenter Study of TranspoCART19 CD19 CAR‑T Cell Therapy in Patients with Refractory Lupus Nephritis: Safety and Preliminary Efficacy
- Evaluation of Mezagitamab (TAK-079) Efficacy and Safety in Adults with Primary IgA Nephropathy: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Trial
Data & Insights
Has run more than one trial at 4 of 52 partner sites.
Specializations
Nephrology and Kidney Transplantation
Clinical research activity is centered on chronic kidney disease, end-stage renal disease, acute kidney injury, and glomerular disorders, with additional involvement in renal transplantation and allograft rejection.
- IgA nephropathy
- Focal segmental glomerulosclerosis
- Kidney transplant
- Delayed graft function
- Prophylaxis of renal allograft rejection
The therapeutic scope includes renal preservation, transplant support, and management of progressive kidney dysfunction.
Cardiovascular Disease and Metabolic Risk
Research interests extend to atherosclerotic cardiovascular disease, heart failure, myocardial infarction, atrial fibrillation, and lipid-related disorders, with attention to patients carrying overlapping metabolic risk.
- Coronary artery disease
- Heart failure with preserved ejection fraction
- Acute ischemic stroke
- Hypertriglyceridemia
- Obesity
Therapeutic involvement includes prevention of vascular events and treatment strategies for cardiometabolic disease.
Oncology and Hematologic Malignancies
Investigational activity covers a broad oncologic portfolio, including solid tumors, lung cancer, breast cancer, urothelial carcinoma, and multiple lymphoid and myeloid malignancies.
- Non-small cell lung cancer
- Multiple myeloma
- Diffuse large B-cell lymphoma
- Metastatic colorectal cancer
- Bladder cancer
The therapeutic emphasis includes targeted oncology, immunotherapy, and disease control across advanced and relapsed cancers.
Immune-Mediated, Inflammatory, and Dermatologic Disorders
There is active involvement in immune-driven conditions such as lupus erythematosus, psoriasis, atopic dermatitis, hidradenitis suppurativa, and bullous pemphigoid, alongside allergic and rheumatologic disease.
- Systemic lupus erythematosus
- Plaque psoriasis
- Atopic dermatitis
- Psoriatic arthritis
- Sjögren’s syndrome
Therapeutic focus includes modulation of immune inflammation, skin disease control, and treatment of chronic autoimmune burden.
Infectious Disease and Respiratory Medicine
Clinical trial involvement also includes HIV infection, COVID-19, pneumonia, and chronic airway disease, with attention to infection prevention and respiratory symptom control.
- HIV-1 infection
- COVID-19
- Asthma
- Chronic obstructive pulmonary disease
- Bronchiectasis
The therapeutic domains include antiviral care, post-infectious recovery, and management of chronic inflammatory lung disease.
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