Clinical Research
person

Hristo M.

Country
Bulgaria
Department
Department of Pneumology and Phthisiatrics

Research Overview

assignment
24
Clinical Trials ·
location_city
1
Research Sites

Data & Insights

medical_services
Primary Speciality
Main therapeutic area

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Return Partnerships
Recurring site collaborations
401
Sites with multiple studies

Has run more than one trial at 401 of 918 partner sites.

Specializations

Asthma and Type 2 Inflammation

Clinical research activity is centered on severe asthma, eosinophilic asthma, and moderate-to-severe asthma, with attention to uncontrolled disease, loss of control, and exacerbation prevention. The portfolio also includes therapies aimed at improving lung function and reducing reliance on maintenance treatment in patients with persistent airway inflammation.

  • Biologic therapy for asthma control
  • Inhaled combination therapy in uncontrolled asthma
  • Asthma exacerbation prevention
  • Type 2 inflammatory airway disease

Interest extends to both adult and pediatric asthma, including mild to moderate asthma and severe uncontrolled asthma, reflecting a strong focus on therapeutic optimization in chronic airway disease.

Chronic Obstructive Pulmonary Disease and Exacerbation Control

Another major area of involvement is COPD, including moderate-to-severe COPD, disease with frequent exacerbations, and chronic bronchitic phenotypes. The research landscape emphasizes reduction of exacerbation burden, improvement of airflow limitation, and long-term disease control in patients with advanced obstructive lung disease.

  • COPD exacerbation reduction
  • Triple inhaled therapy in COPD
  • Severe and uncontrolled obstructive lung disease
  • Long-term COPD management

Work also includes patients with eosinophilic COPD and former smokers, highlighting interest in inflammatory subtypes and therapies designed to improve respiratory outcomes.

Bronchiectasis and Chronic Airway Disorders

Clinical research extends to bronchiectasis and related chronic pulmonary conditions, with a focus on preventing pulmonary exacerbations and addressing ongoing airway morbidity. This area links structural lung disease with therapeutic strategies intended to stabilize respiratory status and reduce clinical deterioration.

  • Bronchiectasis exacerbation prevention
  • Chronic bronchial disease
  • Pulmonary symptom control
  • Airway inflammation

The portfolio reflects engagement with conditions that overlap clinically with obstructive airway disease, supporting innovation in chronic respiratory care.

Viral Respiratory Infections and Antiviral Care

Research activity includes influenza, SARS-CoV-2 infection, and other viral lung infections, with an emphasis on treatment and prevention in respiratory illness. The work also covers infection-related outcomes in vulnerable pediatric and adult populations at risk of progression to severe disease.

  • Influenza treatment and prevention
  • COVID-19 management
  • Severe viral lung infection
  • Antiviral respiratory therapy

Additional involvement in influenza immunisation and vaccine-related studies indicates a broader interest in respiratory infection prevention.

Allergic and Vaccine-Related Respiratory Prevention

The investigator is also involved in seasonal allergic rhinitis and rhinoconjunctivitis linked to grass pollen exposure, alongside preventive immunisation research. This includes respiratory allergy management and studies of vaccines relevant to influenza and other infectious diseases.

  • Grass pollen allergy
  • Seasonal allergic rhinitis
  • Influenza vaccination
  • Preventive immunisation

These interests connect airway allergy care with broader preventive strategies in respiratory medicine.

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