Hendrik Jan V.
- Country
- The Netherlands
- Department
- Pediatrics
Research Overview
- Efficacy and Safety Evaluation of Odevixibat in Pediatric Biliary Atresia Post-Kasai Hepatoportoenterostomy: A Double-Blind, Randomized, Placebo-Controlled Trial
- An Open-label Extension Study to Evaluate Long-term Efficacy and Safety of Odevixibat (A4250) in Children with Biliary Atresia (BOLD-EXT)
- Efficacy and Safety of Obeticholic Acid in Pediatric Patients with Biliary Atresia Post-Hepatoportoenterostomy: A Randomized, Double-Blind, Placebo-Controlled Study
Data & Insights
Has run more than one trial at 21 of 29 partner sites.
Specializations
Pediatric Hepatology
The investigator specializes in treating rare pediatric liver disorders, with particular focus on Alagille Syndrome and Biliary Atresia. Their expertise extends to managing post-surgical cases, specifically children who have undergone hepatoportoenterostomy (Kasai procedure).
- Bile Duct Disorders
- Liver Disease Management
- Post-surgical Care
Their clinical interests encompass long-term patient monitoring and evaluation of novel therapeutic approaches for cholestatic liver diseases.
Therapeutic Innovation
The investigator focuses on evaluating novel treatments for rare hepatic conditions, including odevixibat and obeticholic acid. Their work involves assessing therapeutic interventions for managing symptoms such as pruritus and improving overall liver function.
- Bile Acid Modulation
- Symptom Management
- Long-term Treatment Outcomes
Their research encompasses both immediate therapeutic effects and sustained clinical responses in pediatric liver disorders.
Clinical Outcomes
The investigator's work focuses on critical clinical endpoints including native liver survival and prevention of liver-related complications. They study comprehensive treatment approaches that address both immediate and long-term patient outcomes.
- Liver Function Preservation
- Disease Progression Markers
- Quality of Life Measures
Their research emphasizes monitoring and improving survival rates in children with severe hepatic conditions.
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