Helena C. P.
- Country
- Portugal
- Department
- Gastronterology and Hepatology
Research Overview
- Phase2, double-blind, randomized, placebo-controlled, multicentre study to evaluation the safety, efficacy, and pharmacokinetics of TAK-242 and Granulocyte Colony-Stimulating Factor (G-CSF) (G-TAK) in subjects with severe alcoholic hepatitis (sAH) and acute-on-chronic liver failure (ACLF).
- N1T-MC-MALO: A Master Protocol for a Randomized, Controlled, Clinical Trial of Multiple Pharmacologic Agents in Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease Who Are at Increased Risk of Developing Major Adverse Liver Outcomes (SYNERGY-Outcomes); N1T-MC-TZ01 Tirzepatide in participants with high-risk MASLD; N1T-MC-RT01 Retatrutide in participants with high-risk MASLD
- Phase III Randomized Double‑Blind Placebo‑Controlled Study of Oral Elafibranor 120 mg in Adults with Primary Sclerosing Cholangitis
Data & Insights
Has run more than one trial at 120 of 283 partner sites.
Specializations
Gastroenterology and Hepatic Disease
Helena Cortez-Pinto is involved in clinical research across inflammatory bowel disease, including ulcerative colitis, Crohn’s disease, and broader gastrointestinal inflammation. Her portfolio also includes liver-focused therapeutic areas such as metabolic dysfunction-associated steatotic liver disease, non-alcoholic steatohepatitis, primary sclerosing cholangitis, primary biliary cholangitis, Wilson disease, and acute-on-chronic liver failure.
- Inflammatory bowel disease
- Metabolic liver disease
- Cholestatic liver disorders
- Acute hepatic decompensation
Her trial activity also touches on eosinophilic esophagitis and other digestive tract conditions linked to immune-mediated and chronic hepatobiliary disease.
Autoimmune and Immune-Mediated Disorders
Her research landscape includes multiple autoimmune diseases and systemic inflammatory conditions, with activity in systemic lupus erythematosus, lupus nephritis, Sjögren’s disease, systemic sclerosis, rheumatoid arthritis, psoriatic arthritis, and juvenile idiopathic arthritis. She is also involved in studies addressing giant cell arteritis, polymyalgia rheumatica, and idiopathic inflammatory myopathies.
- Systemic autoimmune disease
- Connective tissue disease
- Inflammatory arthritis
- Vasculitis
Her clinical trial involvement extends to hidradenitis suppurativa, prurigo nodularis, and other immune-mediated skin and multisystem disorders.
Cardiovascular and Thrombotic Medicine
Her clinical research activity includes atherosclerotic cardiovascular disease, hypertension, heart failure, atrial fibrillation, acute coronary syndrome, myocardial infarction, stroke prevention, and aortic stenosis. She is also involved in studies addressing cardiovascular risk reduction and anticoagulation reversal.
- Heart failure
- Atrial fibrillation
- Ischemic stroke prevention
- Structural heart disease
Her portfolio reflects interest in both chronic cardiometabolic disease and acute vascular events, including cardiorenal complications and thromboembolic risk.
Respiratory and Pulmonary Disease
She is active in therapeutic areas covering asthma, chronic obstructive pulmonary disease, bronchiectasis, idiopathic pulmonary fibrosis, pulmonary arterial hypertension, and pulmonary hypertension associated with interstitial lung disease. Her trial involvement also includes cystic fibrosis and other chronic lung conditions.
- Airway inflammation
- Chronic obstructive lung disease
- Pulmonary vascular disease
- Fibrotic lung disease
Her research spans both obstructive and interstitial respiratory disorders, with emphasis on long-term disease control and symptom burden.
Oncology and Hematologic Malignancies
Her clinical trial portfolio includes a broad range of solid tumors and hematologic malignancies, with involvement in breast cancer, non-small cell lung cancer, colorectal cancer, gastric cancer, head and neck squamous cell carcinoma, bladder cancer, ovarian cancer, prostate cancer, and renal cell carcinoma. She also participates in studies in acute myeloid leukemia, lymphoma, multiple myeloma, and myelofibrosis.
- Breast oncology
- Lung cancer
- Gastrointestinal oncology
- Hematologic cancer
Her oncology interests also extend to immunotherapy, targeted therapy, and treatment areas linked to advanced or metastatic disease.
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