Heike K.
- Country
- Germany
- Department
- Klinik fuer Kinderheilkunde I
Research Overview
- Phase 3 Randomized Double‑Blind Placebo‑Controlled Study of Single Intravenous SGT‑003 Gene Therapy in Ambulant Male Patients with Duchenne Muscular Dystrophy
- Efficacy and Safety Evaluation of Givinostat in Non-Ambulant Duchenne Muscular Dystrophy: A Randomized, Double-Blind, Placebo-Controlled Multicenter Trial
- Long-term neuropsychologic outcome of pre-emptive mTOR inhibitor treatment in children with tuberous sclerosis complex (TSC) under 4 months of age (PROTECT)
Data & Insights
Has run more than one trial at 22 of 57 partner sites.
Specializations
Pediatric Oncology and Hematologic Malignancies
Clinical research activity includes acute lymphoblastic leukemia, acute myeloid leukemia, lymphoma, and other childhood and adolescent cancers, with particular attention to relapsed or refractory disease and high-risk presentations.
- Acute lymphoblastic leukemia
- Acute myeloid leukemia
- Diffuse large B-cell lymphoma
- Hodgkin lymphoma
Work also extends to neuroblastoma, medulloblastoma, glioblastoma, and pediatric low-grade glioma, reflecting a strong focus on innovative treatment options for pediatric solid and central nervous system tumors.
Solid Tumors and Precision Oncology
Research involvement is broad across advanced and metastatic solid tumors, with emphasis on non-small cell lung cancer, breast cancer, colorectal cancer, and melanoma, including biomarker-defined and treatment-resistant disease.
- Non-small cell lung cancer
- Breast cancer
- Colorectal cancer
- Melanoma
Additional interests include urothelial carcinoma, hepatocellular carcinoma, gastrointestinal stromal tumor, and head and neck squamous cell carcinoma, supporting therapeutic development in genomically selected and late-stage cancers.
Autoimmune, Inflammatory, and Neurologic Disorders
The investigator is engaged in studies of immune-mediated diseases such as multiple sclerosis, Crohn’s disease, ulcerative colitis, systemic lupus erythematosus, and myasthenia gravis.
- Multiple sclerosis
- Crohn’s disease
- Ulcerative colitis
- Myasthenia gravis
Other therapeutic areas include chronic spontaneous urticaria, thyroid eye disease, psoriasis, and hidradenitis suppurativa, indicating involvement in both systemic autoimmune and chronic inflammatory conditions.
Renal, Transplant, and Rare Disease Medicine
Research interests cover chronic kidney disease, IgA nephropathy, lupus nephritis, rapidly progressive glomerulonephritis, and kidney transplantation, alongside other renal immune disorders.
- Chronic kidney disease
- IgA nephropathy
- Lupus nephritis
- Kidney transplantation
Additional activity includes amyloidosis, beta-thalassemia, spinal muscular atrophy, and Duchenne muscular dystrophy, showing participation in rare disease programs with significant unmet therapeutic need.
Cardiometabolic, Respiratory, and Critical Care Conditions
Clinical trial involvement also spans cardiovascular disease, heart failure, atrial fibrillation, acute coronary syndrome, and stroke, with attention to prevention and acute management.
- Cardiovascular disease
- Heart failure
- Atrial fibrillation
- Acute coronary syndrome
Further work includes chronic obstructive pulmonary disease, asthma, bronchiectasis, severe pneumonia, and critical illness, reflecting a therapeutic interest in complex internal medicine and intensive care settings.
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