Heike B.
- Country
- Germany
- Department
- Department of Gastroenterology and Hepatology
Research Overview
- A multi-center, double-blind, randomized, placebo-controlled, 2-way cross-over post approval study to investigate the efficacy of daridorexant in subjects with insomnia and comorbid nocturia
- Phase 3 Randomized Double‑Blind Placebo‑Controlled Trial of ALKS 2680 for Excessive Daytime Sleepiness in Adults with Narcolepsy Type 2
- Randomized, Double‑Blind, Placebo‑Controlled Trial of E2086 for Reducing Excessive Daytime Sleepiness in Adults with Narcolepsy
Data & Insights
Has run more than one trial at 117 of 310 partner sites.
Specializations
Gastroenterology and Hepatology
Clinical research activity centers on chronic liver disease, cholestatic disorders, and metabolic liver disease, with involvement in studies of primary sclerosing cholangitis, primary biliary cholangitis, cirrhosis, hepatic encephalopathy, hepatocellular carcinoma, and nonalcoholic steatohepatitis.
- Primary Sclerosing Cholangitis
- Primary Biliary Cholangitis
- Hepatocellular Carcinoma
- Metabolic Dysfunction-Associated Steatohepatitis
- Hepatic Encephalopathy
The therapeutic focus also extends to pruritus linked to hepatobiliary disease and to advanced fibrotic liver conditions requiring disease-modifying treatment options.
Inflammatory Bowel Disease and Autoimmune Gastrointestinal Disorders
Research involvement includes Crohn’s disease, ulcerative colitis, and related immune-mediated intestinal inflammation, with interest in therapies aimed at controlling mucosal disease activity and reducing symptom burden.
- Crohn’s Disease
- Ulcerative Colitis
- Moderately to Severely Active Inflammatory Bowel Disease
- Gastrointestinal Immune-Mediated Inflammation
Work in this area reflects a therapeutic emphasis on anti-inflammatory biologic treatment and long-term control of relapsing intestinal disease.
Autoimmune and Systemic Inflammatory Disease
Clinical trial activity spans systemic lupus erythematosus, Sjögren’s disease, systemic sclerosis, myositis, psoriatic arthritis, and axial spondyloarthritis, alongside other immune-mediated rheumatic conditions.
- Systemic Lupus Erythematosus
- Sjögren’s Disease
- Systemic Sclerosis
- Idiopathic Inflammatory Myopathy
- Axial Spondyloarthritis
The therapeutic landscape includes interventions targeting immune dysregulation, inflammatory activity, and associated organ involvement.
Renal and Complement-Mediated Disease
Research interests include IgA nephropathy, focal segmental glomerulosclerosis, membranoproliferative glomerulonephritis, rapidly progressive glomerulonephritis, and chronic kidney disease, with a strong focus on immune-driven renal injury.
- IgA Nephropathy
- Focal Segmental Glomerulosclerosis
- Complement-Mediated Glomerulopathy
- Rapidly Progressive Glomerulonephritis
- Chronic Kidney Disease
This area also includes proteinuria and transplant-related renal complications, supporting work in kidney-protective and immunomodulatory therapy.
Cardiopulmonary and Systemic Complications
Additional trial involvement covers pulmonary arterial hypertension, interstitial lung disease, progressive pulmonary fibrosis, heart failure, and atherosclerotic cardiovascular disease, with attention to complex inflammatory and fibrotic complications.
- Pulmonary Arterial Hypertension
- Interstitial Lung Disease
- Progressive Pulmonary Fibrosis
- Heart Failure
- Atherosclerotic Cardiovascular Disease
Her research landscape also reaches autoimmune lung disease and cardiorenal overlap syndromes, where therapeutic innovation is aimed at limiting progression and organ damage.
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