Hans P.
- Country
- The Netherlands
- Department
- Cardiology
Research Overview
- A Randomized, Placebo‑Controlled Trial of Zenagamtide (NNC0487‑0111) in Obese Patients with HFpEF or HFmrEF to Reduce CV Death and HF Hospitalization
- TRITON-CM: A Phase 3 Global, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Nucresiran in Patients with Transthyretin-Mediated Amyloidosis with Cardiomyopathy (ATTR amyloidosis with cardiomyopathy)
Data & Insights
Has run more than one trial at 32 of 325 partner sites.
Specializations
Cardiovascular Disease and Thrombosis
Clinical research in cardiology centered on atherosclerotic cardiovascular disease, acute coronary syndrome, myocardial infarction, atrial fibrillation, stroke prevention, and coronary vasospasm. The therapeutic scope also includes heart failure, peripheral arterial disease, cardiovascular risk reduction, and lipoprotein(a)-related disease.
- Major adverse cardiovascular events
- Antithrombotic therapy
- Coronary artery disease
- Atrial fibrillation
- Stroke prevention
Research interest extends to treatment strategies for post-myocardial infarction care, secondary prevention, and vascular protection in patients with elevated cardiovascular risk.
Gastrointestinal and Pancreatic Oncology
Active involvement in trials for colorectal cancer, rectal cancer, gastric cancer, esophagogastric cancer, and pancreatic cancer, with attention to resectable, locally advanced, recurrent, and metastatic disease settings. The therapeutic focus includes perioperative and adjuvant approaches across digestive tract malignancies.
- Colorectal cancer
- Rectal cancer
- Gastric and gastroesophageal junction cancer
- Pancreatic cancer
- Peritoneal metastases
Additional interests include hyperthermic intraperitoneal chemotherapy, surgical oncology, and treatment optimization for advanced gastrointestinal malignancies.
Hematologic Malignancies
Clinical trial activity spans acute myeloid leukemia, myelodysplastic syndrome, chronic lymphocytic leukemia, diffuse large B-cell lymphoma, multiple myeloma, and related high-risk lymphoid and myeloid disorders. The therapeutic landscape includes both newly diagnosed and relapsed or refractory disease.
- Acute myeloid leukemia
- Chronic lymphocytic leukemia
- Diffuse large B-cell lymphoma
- Myelodysplastic syndrome
- Multiple myeloma
Research also covers treatment combinations in lymphoma and leukemia, with interest in improving disease control and limiting treatment-related toxicity.
Thoracic, Inflammatory, and Respiratory Diseases
Investigator involvement includes pulmonary sarcoidosis, idiopathic pulmonary fibrosis, asthma, chronic cough, bronchiectasis, and chronic obstructive pulmonary disease. The therapeutic emphasis is on chronic respiratory disorders with inflammatory or fibrotic mechanisms.
- Idiopathic pulmonary fibrosis
- Pulmonary sarcoidosis
- Severe asthma
- Chronic cough
- Bronchiectasis
Research also includes esophageal cancer and pleural mesothelioma, reflecting interest in thoracic oncology alongside respiratory medicine.
Gynecologic, Urologic, and Endocrine Conditions
Clinical research extends to prostate cancer, bladder cancer, urothelial cancer, endometrial cancer, cervical cancer, ovarian cancer, and vulvar disease, with a strong surgical and medical oncology component. Additional work addresses infertility, polycystic ovary syndrome, uterine fibroids, and late-onset hypogonadism.
- Prostate cancer
- Endometrial cancer
- Cervical cancer
- Ovarian cancer
- Infertility
Therapeutic interests also include fertility-sparing treatment, hormone-related disease, and management of malignancies requiring integrated systemic and surgical care.
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