H.N.A.J. V. R.
- Country
- The Netherlands
- Department
- Pulmonary Science
Research Overview
Data & Insights
Has run more than one trial at 2 of 39 partner sites.
Specializations
Pulmonary oncology
Clinical research in non-small cell lung cancer and small cell lung cancer with interest in targeted therapy, immunotherapy, and treatment selection for advanced thoracic malignancies.
- Advanced and metastatic NSCLC
- RET fusion-positive lung cancer
- EGFR-mutated lung cancer
- Extensive-stage and limited-stage SCLC
Work also extends to lung cancer subtypes defined by molecular alterations and treatment resistance patterns.
Cardiovascular disease and thrombosis
Research activity includes acute myocardial infarction, acute coronary syndrome, atrial fibrillation, stroke, and broader atherosclerotic cardiovascular disease prevention.
- Myocardial infarction
- Non-ST-segment elevation acute coronary syndrome
- Ischemic stroke and transient ischemic attack
- Primary prevention of cardiovascular events
Additional interests include antithrombotic strategies, lipid-lowering therapy, and inflammation-driven cardiovascular risk reduction.
Hematologic malignancies
Clinical involvement covers chronic lymphocytic leukemia, diffuse large B-cell lymphoma, mantle cell lymphoma, acute myeloid leukemia, and other aggressive blood cancers.
- CLL and SLL
- DLBCL and high-grade B-cell lymphoma
- Acute myeloid leukemia
- Myelodysplastic syndrome
The research portfolio also includes immune-based and targeted approaches for relapsed or high-risk hematologic disease.
Digestive and pancreatic oncology
Research spans pancreatic cancer, colorectal cancer, rectal cancer, and gastric cancer, with attention to perioperative and systemic treatment strategies.
- Borderline resectable pancreatic cancer
- Metastatic colorectal cancer
- Locally recurrent rectal cancer
- Gastric adenocarcinoma
Related work includes liver metastases and surgical infection prevention in upper gastrointestinal procedures.
Respiratory and immune-mediated disorders
Interest also extends to chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, pulmonary sarcoidosis, pneumonia, and respiratory tract infection.
- Idiopathic pulmonary fibrosis
- COPD
- Acute respiratory distress syndrome
- Infectious and inflammatory lung disease
Additional therapeutic focus includes multiple sclerosis and other immune-mediated conditions linked to chronic inflammation.
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