Guntis K.
- Country
- Latvia
- Department
- Neurology and Neurosurgery department
Research Overview
- Phase 3 Randomized Trial of Human Normal Immunoglobulin to Prevent Infections in IgG‑deficient Patients with Autoimmune/Rheumatic Disease on B‑cell Depletion Therapy
- Evaluation of LSTA1 Combined with Temozolomide Versus Temozolomide Alone in Newly Diagnosed Glioblastoma Multiforme: A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study
- A Multicenter, Open-label, Long-term, Safety, Tolerability, and Efficacy Study of XEN1101 in Subjects Diagnosed With Epilepsy (X-TOLE4)
Data & Insights
Has run more than one trial at 212 of 537 partner sites.
Specializations
Cardiovascular Medicine
The clinical research profile includes extensive involvement in atherosclerotic cardiovascular disease, acute myocardial infarction, acute coronary syndrome, and atrial fibrillation, with additional focus on stroke prevention and heart failure.
- Major adverse cardiovascular events
- Thromboembolic risk reduction
- Heart failure with preserved and reduced ejection fraction
- Secondary prevention after ischemic stroke
Research activity also spans systemic inflammation in cardiovascular disease, hypertriglyceridemia, and prevention of recurrent vascular events.
Respiratory and Pulmonary Disease
Clinical trial involvement covers asthma, chronic obstructive pulmonary disease, and lung cancer across both early and advanced disease settings.
- Asthma control and exacerbation prevention
- Chronic obstructive pulmonary disease with type 2 inflammation
- Non-small cell lung cancer
- Small cell lung cancer
The therapeutic landscape includes perioperative treatment, adjuvant oncology, and advanced thoracic malignancy management.
Autoimmune, Neurologic, and Inflammatory Disorders
Research interests include systemic lupus erythematosus, psoriatic arthritis, relapsing multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, and seizure disorders.
- Autoimmune rheumatic disease
- Demyelinating disease
- Epilepsy and focal-onset seizures
- Immune-mediated inflammation
Additional involvement extends to immunoglobulin replacement for infection prevention in immune-compromised patients and to inflammatory eye disease.
Oncology and Hematologic Malignancies
The oncology portfolio includes advanced solid tumors, gastric and gastroesophageal junction adenocarcinoma, glioblastoma multiforme, prostate cancer, and bladder cancer.
- Non-small cell lung cancer and metastatic disease
- Genitourinary malignancies
- Central nervous system tumors
- Precision oncology and biomarker-defined cancer
Trial involvement also covers adjuvant cancer therapy, immunotherapy combinations, and treatment strategies for HRR-mutated and HRD-positive cancers.
Ophthalmology and Infectious Disease
Clinical work also includes thyroid eye disease and neovascular age-related macular degeneration, alongside studies in complicated urinary tract infection, acute pyelonephritis, and severe hospital-acquired infections.
- Orbital inflammatory disease
- Retinal neovascular disorders
- Complicated bacterial infection
- Antimicrobial treatment of resistant pathogens
The infectious disease focus extends to pneumonia and complicated intra-abdominal infection in hospitalized adult patients.
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