Grethe B. S.
- Country
- Denmark
- Department
- Department of Otorhinolaryngology and Head & Neck Cancer
Research Overview
- Evaluation of Biologic Tapering with Mepolizumab and Dupilumab in Patients with Severe Chronic Rhinosinusitis with Nasal Polyps: A Danish RCT
- A Phase 2b, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of the Efficacy and Safety of Brensocatib in Participants with Chronic Rhinosinusitis Without Nasal Polyps – The BiRCh Study
Data & Insights
Has run more than one trial at 3 of 55 partner sites.
Specializations
Otorhinolaryngology and Nasal Disease
Clinical research in chronic rhinosinusitis, including both chronic rhinosinusitis with nasal polyposis and chronic rhinosinusitis without nasal polyps, with a focus on symptom control, biologic treatment adjustment, and disease remission in persistent upper airway inflammation.
- Chronic rhinosinusitis with nasal polyposis
- Chronic rhinosinusitis without nasal polyps
- Biologic therapy tapering in nasal disease
Interest also extends to targeted management of nasal obstruction and inflammatory airway conditions within otorhinolaryngology.
Respiratory Infection and Airway Inflammation
Active involvement in studies of community-acquired pneumonia, viral lung infection, COVID-19, and chronic obstructive pulmonary disease, with emphasis on infection-related respiratory deterioration and host response in vulnerable patients.
- Community-acquired pneumonia
- COVID-19
- Chronic obstructive pulmonary disease (COPD)
Research interests include respiratory protection, symptom reduction, and prevention of progression in high-risk pulmonary disease.
Cardiovascular and Metabolic Disease
Clinical work spans heart failure, atrial fibrillation, myocardial infarction, stroke prevention, and cardiometabolic risk in type 1 diabetes and type 2 diabetes, including prevention of vascular and renal complications.
- Heart failure and pulmonary congestion
- Atrial fibrillation and stroke prevention
- Diabetes mellitus with cardiovascular risk
Therapeutic interest also includes fluid management, residual inflammatory risk, and cardiovascular protection in patients with complex comorbidity.
Gastrointestinal and Inflammatory Bowel Disease
Research activity includes Crohn’s disease and ulcerative colitis, with attention to controlling intestinal inflammation, improving remission, and optimizing longer-term treatment strategies in chronic immune-mediated bowel disease.
- Crohn’s disease
- Ulcerative colitis
- Inflammatory bowel disease
This area reflects engagement with therapeutic approaches aimed at reducing active mucosal disease and maintaining durable disease control.
Infectious Disease, Critical Care, and Acute Management
Clinical trial involvement covers sepsis, septic shock, Gram-negative bacteremia, Staphylococcus aureus bacteremia, pyogenic vertebral osteomyelitis, and acute interstitial nephritis, alongside acute care interventions for hospitalized and critically ill patients.
- Sepsis and septic shock
- Bacteremia and deep bacterial infection
- Critical care interventions
Additional interest includes acute symptom relief and infection-focused treatment in emergency and intensive care settings.
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