Girolama Alessandra M.
- Country
- Italy
- Department
- UOSD Centro Scelerosi Multipla
Research Overview
- Efficacy and Safety of Remibrutinib in Patients with Secondary Progressive Multiple Sclerosis: A Phase III, Randomized, Double-Blind, Placebo-Controlled Study
- Phase III Open‑Label Single‑Arm Multicenter Study of On‑Body Delivery System for Subcutaneous High‑Concentration Ocrelizumab in Adults with Multiple Sclerosis
- Evaluation of Ocrelizumab Efficacy and Safety in Multiple Sclerosis Patients from a Prior Phase IIIb/IV Trial
Data & Insights
Has run more than one trial at 294 of 474 partner sites.
Specializations
Multiple Sclerosis and Neuroimmunology
Clinical research is centered on multiple sclerosis, including relapsing, primary progressive, and secondary progressive forms, as well as radiologically isolated syndrome and other inflammatory central nervous system disorders. The therapeutic landscape also includes agents aimed at controlling neuroinflammation and preserving neurologic function.
- Relapsing multiple sclerosis
- Primary progressive multiple sclerosis
- Progressive forms of multiple sclerosis
- Chronic inflammatory demyelinating polyneuropathy
- Generalized myasthenia gravis
Additional activity extends to ocrelizumab and other therapies relevant to immune-mediated neurologic disease, with attention to disease control and long-term neurologic outcomes.
Gastroenterology and Inflammatory Bowel Disease
Research involvement includes Crohn’s disease, ulcerative colitis, and related inflammatory bowel disorders, with a strong therapeutic focus on biologic and targeted approaches for intestinal inflammation and symptom control.
- Crohn’s disease
- Ulcerative colitis
- Moderately to severely active Crohn’s disease
- Bowel urgency
- Transmural healing
Therapeutic interest also includes interleukin-targeted and JAK inhibitor strategies, reflecting a broad commitment to improving inflammatory disease control.
Hematology and Myeloid Malignancies
Clinical trial activity covers myelodysplastic syndromes, acute myeloid leukemia, chronic myeloid leukemia, chronic lymphocytic leukemia, and other hematologic cancers, with emphasis on cytopenias, remission, and disease-directed treatment.
- Myelodysplastic syndromes
- Acute myeloid leukemia
- Chronic lymphocytic leukemia
- Multiple myeloma
- Chronic myelomonocytic leukemia
Research interests also include transfusion dependence, molecularly defined leukemia subtypes, and treatment strategies for higher-risk marrow disorders.
Dermatology and Immune-Mediated Skin Disease
Investigator activity includes psoriasis, atopic dermatitis, hidradenitis suppurativa, prurigo nodularis, and actinic keratosis, with a therapeutic focus on chronic inflammatory skin disease and lesion-directed care.
- Moderate to severe plaque psoriasis
- Atopic dermatitis
- Hidradenitis suppurativa
- Prurigo nodularis
- Actinic keratosis
Additional interest extends to chronic inducible urticaria, alopecia areata, and other immune-driven dermatologic conditions.
Retinal, Metabolic, and Cardiovascular Disorders
Research engagement also spans age-related macular degeneration, diabetic macular edema, glaucoma, obesity, hypercholesterolemia, and atherosclerotic cardiovascular disease, showing interest in chronic conditions with major visual and cardiometabolic impact.
- Geographic atrophy
- Diabetic macular edema
- Glaucoma
- Obesity
- Stroke prevention
Therapeutic themes include intravitreal treatment, lipid lowering, and thrombotic risk reduction in diseases affecting vision and vascular health.
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