Giorgio F.
- Country
- Italy
- Department
- Oncologia
Research Overview
- Phase 2 Randomized, Blinded, Placebo-Controlled Study of INBRX-109 in Adults with Unresectable or Metastatic Conventional Chondrosarcoma
- Phase 3 Double-Blind Study of Ivosidenib in Adults with IDH1-Mutant Locally Advanced or Metastatic Conventional Chondrosarcoma
- Phase 4 Open-Label Study of Nirogacestat in Premenopausal Females with Desmoid Tumors/Aggressive Fibromatosis to Assess Ovarian Function Recovery Rate
Data & Insights
Has run more than one trial at 22 of 58 partner sites.
Specializations
Soft Tissue and Bone Sarcomas
Giorgio Frega’s clinical research is centered on advanced sarcoma care, with strong involvement in soft tissue sarcoma and bone sarcoma subtypes such as leiomyosarcoma, liposarcoma, undifferentiated pleomorphic sarcoma, chondrosarcoma, and Ewing sarcoma.
- Metastatic leiomyosarcoma
- Conventional chondrosarcoma
- Ewing sarcoma
- Undifferentiated pleomorphic sarcoma
- Liposarcoma
His trial portfolio includes treatment strategies for unresectable, metastatic, and recurrent disease, reflecting a focus on therapeutic innovation in difficult-to-treat oncologic settings.
Tenosynovial Giant Cell Tumor and Desmoid Disease
He is also active in the management of tenosynovial giant cell tumor and desmoid tumor/aggressive fibromatosis, with attention to tumor control and symptom relief in locally aggressive disease.
- Tenosynovial giant cell tumor
- Desmoid tumor
- Aggressive fibromatosis
- Advanced tumors
This area links oncologic treatment with disease stabilization in rare soft-tissue neoplasms.
Pediatric and Adolescent Bone Oncology
Another major interest is pediatric and adolescent sarcoma, including relapsed or refractory Ewing sarcoma and high-risk osteosarcoma, where the clinical emphasis is on disease control in aggressive bone malignancies.
- Recurrent Ewing sarcoma
- Primary refractory Ewing sarcoma
- Metastatic osteosarcoma
- High-risk relapse bone sarcoma
His work in this field supports the evaluation of novel systemic options for patients with limited standard therapeutic choices.
Bone Fragility and Orthopedic Regeneration
Giorgio Frega’s research extends beyond oncology into bone fragility disorders and orthopedic healing, including osteogenesis imperfecta and delayed union or non-union of long bone fractures.
- Osteogenesis imperfecta
- Delayed consolidation
- Long bone fracture non-union
- Bone repair
His clinical interests also cover regenerative approaches involving mesenchymal stromal cells and biomaterial-based bone reconstruction.
Inflammatory Musculoskeletal Disease
He is involved in studies of axial spondyloarthritis and rotator cuff tendinopathy, indicating a therapeutic interest in inflammatory and degenerative musculoskeletal conditions.
- Axial spondyloarthritis
- Non-radiographic axial spondyloarthritis
- Rotator cuff tendinopathy
- Shoulder symptom control
These areas broaden his clinical portfolio into chronic musculoskeletal disease management alongside oncologic research.
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