Gildas B.
- Country
- France
- Department
- Internal Medicine-Immune Hematology Clinic
Research Overview
Data & Insights
Has run more than one trial at 0 of 32 partner sites.
Specializations
Hematologic Malignancies
Investigator focuses on therapeutic strategies for multiple myeloma, follicular lymphoma and peripheral T‑cell lymphoma.
- Combination immunotherapy with daratumumab and lenalidomide
- Subcutaneous versus intravenous monoclonal antibody delivery
- Post‑transplant consolidation and maintenance approaches
Emphasis is placed on extending progression‑free survival and achieving deep minimal residual disease responses.
Myelodysplastic Syndromes
Research targets lower‑risk myelodysplastic syndrome without ring sideroblasts, particularly patients refractory to erythropoiesis‑stimulating agents.
- Luspatercept combined with erythropoietin
- Timing of erythropoietin initiation
- Transfusion independence outcomes
Goals include improving hematologic parameters and reducing transfusion burden.
Infectious Diseases
Investigator evaluates treatments for serious infections such as Staphylococcus aureus bacteremia, chronic pulmonary aspergillosis and Mycobacterium avium complex lung disease.
- Single‑dose dalbavancin versus standard antibiotic courses
- Itraconazole with nebulised liposomal amphotericin B
- Azithromycin versus clarithromycin regimens
Studies aim to optimize efficacy while minimizing treatment duration and resistance.
Autoimmune and Dermatologic Conditions
Clinical work includes immune thrombocytopenia and progressive vitiligo, exploring immune modulation strategies.
- Combined belimumab and rituximab therapy
- Methotrexate with narrowband UVB phototherapy
- Vaccination strategies to enhance immune protection in hematologic patients
Focus is on restoring immune balance and achieving clinical remission.
Cardiovascular and Thrombotic Disorders
Investigator addresses cardiovascular risk in hematology patients, including acute coronary syndrome, atrial fibrillation and thrombosis prevention in myeloproliferative neoplasms.
- Low‑dose direct oral anticoagulants versus aspirin
- Implantable monitoring devices for anticoagulation management
- Evaluation of antithrombotic strategies in JAK2V617F‑positive disease
Research seeks to balance bleeding risk with effective thromboprophylaxis.
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