Ghoufrane T.
- Country
- France
- Department
- Médecine nucléaire
Research Overview
- 68Ga-FAPI-46 PET-CT for Initial Staging of Curatively Treated Gastric Adenocarcinoma
- Phase IIb Trial of Everolimus and Lutetium (177Lu) Oxodotreotide in Refractory Grade 2 and 3 Meningioma
- Evaluation of Retreatment Protocols with Lutetium (177Lu) Oxodotreotide in Patients with Progressive Intestinal Well-Differentiated Neuroendocrine Tumors
Data & Insights
Has run more than one trial at 13 of 31 partner sites.
Specializations
Hematology and Blood Cancers
Clinical activity includes acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndromes, and lymphoma, with interest across relapsed, refractory, and newly diagnosed hematologic malignancies.
- Myelodysplastic syndromes and myelofibrosis
- B-cell and T-cell lymphomas
- Multiple myeloma and related plasma cell disorders
Work in this area also extends to hematopoietic stem cell transplantation and graft-versus-host disease in hematologic disease management.
Solid Tumors and Precision Oncology
Research involvement spans non-small cell lung cancer, urothelial carcinoma, hepatocellular carcinoma, colorectal cancer, and other advanced solid tumors, with emphasis on biomarker-defined and metastatic disease.
- Lung cancer and head and neck cancer
- Renal cell carcinoma and urothelial cancer
- Gastrointestinal and hepatobiliary malignancies
The therapeutic focus includes targeted therapy and immuno-oncology approaches in advanced cancer care.
Autoimmune and Inflammatory Diseases
Clinical interests include rheumatoid arthritis, systemic lupus erythematosus, Crohn’s disease, ulcerative colitis, and systemic sclerosis, reflecting broad activity in immune-mediated disorders.
- Connective tissue diseases
- Inflammatory bowel disease
- Vasculitis and autoimmune cytopenias
Additional involvement is seen in myasthenia gravis, sarcoidosis, and other refractory inflammatory conditions requiring advanced immunomodulation.
Pulmonary and Infectious Diseases
Research spans asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, bronchiectasis, and pulmonary hypertension, alongside selected infectious lung diseases.
- Chronic pulmonary aspergillosis
- Nontuberculous mycobacterial lung infection
- Severe asthma and eosinophilic airway disease
Interest also includes respiratory infection prevention and complex pulmonary complications in immunocompromised settings.
Cardiovascular, Renal, and Neurologic Conditions
Clinical trial involvement covers acute myocardial infarction, atrial fibrillation, stroke, chronic kidney disease, and kidney transplantation, with additional activity in neurologic disorders.
- Heart failure and valvular disease
- Acute kidney injury and transplant rejection
- Multiple sclerosis and neurodegenerative disease
Therapeutic interest also extends to amyloidosis, hypertension, and thrombotic and vascular complications.
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