Gerrina R.
- Country
- The Netherlands
- Department
- Medical Oncology Department
Research Overview
- Dose-Escalation Study of Zongertinib in Patients with Advanced Non-Small Cell Lung Cancer and Solid Tumors with HER2 Aberrations
- Phase 1 Study of SHP2 Inhibitor BBP-398 and KRAS-G12C Inhibitor Sotorasib in Advanced Solid Tumors with KRAS-G12C Mutation
- Evaluation of STX-721 in Patients with Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring Specific Mutations
Data & Insights
Has run more than one trial at 130 of 282 partner sites.
Specializations
Thoracic Oncology
Clinical research activity includes non-small cell lung cancer, small cell lung carcinoma, and other advanced thoracic malignancies, with attention to molecularly defined disease such as EGFR-, ALK-, ROS1-, and KRAS G12C-altered tumors.
- Advanced NSCLC
- Small cell lung cancer
- Driver-mutated lung cancer
- Pleural mesothelioma
Therapeutic interest also extends to immunotherapy, targeted therapy, and combination approaches for advanced lung and pleural cancers.
Gastrointestinal and Hepatobiliary Cancers
Research involvement spans colorectal cancer, rectal cancer, gastric cancer, gastroesophageal junction adenocarcinoma, esophageal squamous cell carcinoma, and biliary tract cancer, including biomarker-defined advanced solid tumors.
- Colorectal and rectal malignancies
- Gastric and GEJ adenocarcinoma
- Esophageal cancer
- Biliary tract cancer
Additional interest is seen in gastrointestinal stromal tumor and neuroendocrine tumors, reflecting a broad focus on gastrointestinal oncology.
Genitourinary and Gynecologic Oncology
Clinical trial activity covers urothelial carcinoma, bladder cancer, renal cell carcinoma, and prostate cancer, alongside gynecologic cancers such as cervical cancer, endometrial carcinoma, ovarian cancer, and vulvar squamous cell carcinoma.
- Urothelial and bladder malignancies
- Renal cell carcinoma
- Prostate cancer
- Cervical, endometrial, and ovarian cancers
Therapeutic interests include checkpoint inhibition, perioperative treatment strategies, and organ-preserving approaches in selected pelvic cancers.
Melanoma, Head and Neck, and Rare Solid Tumors
Research also includes melanoma, head and neck squamous cell carcinoma, cutaneous squamous cell carcinoma, sarcoma, and other rare advanced solid tumors, including mesothelioma and germ cell tumors.
- Melanoma
- Head and neck squamous cell carcinoma
- Sarcoma
- Rare advanced solid tumors
There is also involvement in biomarker-driven treatment for tumors with HER2 alterations, MSI-H/dMMR status, and other actionable molecular features.
Precision Oncology and Supportive Therapeutics
The clinical landscape includes molecularly selected solid tumors, advanced malignancies, and supportive care areas such as opioid-induced constipation and platinum-related ototoxicity.
- Biomarker-selected solid tumors
- Advanced metastatic disease
- Supportive oncology
- Therapy-related toxicity prevention
Work in this area reflects interest in personalized cancer treatment and the management of treatment-related complications across multiple tumor types.
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