Fritz D.
- Country
- Spain
- Department
- Nephrology
Research Overview
- Evaluation of Autologous Tolerogenic Dendritic Cells in Highly Sensitized Patients Undergoing Kidney Transplantation
- Evaluation of Tegoprubart Versus Tacrolimus in Prophylaxis of Renal Allograft Rejection in Kidney Transplant Recipients
- Evaluation of Imlifidase for Achieving Negative Virtual Crossmatch in Highly Sensitized Patients Undergoing Living Donor Renal Transplantation
Data & Insights
Has run more than one trial at 36 of 53 partner sites.
Specializations
Nephrology and Kidney Transplantation
Clinical research includes chronic kidney disease, IgA nephropathy, focal segmental glomerulosclerosis, lupus nephritis, anca-associated vasculitis, and Alport syndrome, with a strong focus on kidney transplantation, renal allograft rejection, delayed graft function, and highly sensitised recipients.
- Kidney transplantation and graft outcomes
- Glomerular and immune-mediated renal disease
- Renal failure and albuminuria
Also involved in studies addressing renal transplant compatibility, allograft protection, and kidney-related complications in complex systemic disease.
Hematologic Malignancies and Cellular Therapy
Research activity spans acute myeloid leukemia, myelodysplastic syndromes, multiple myeloma, chronic lymphocytic leukemia, diffuse large B-cell lymphoma, mantle cell lymphoma, and other B-cell malignancies, with interest in CAR T-cell therapy and autologous stem cell transplantation.
- Leukemia and myelodysplastic neoplasms
- Plasma cell disorders
- Lymphoma-directed immunotherapy
Therapeutic involvement also includes relapsed and refractory disease, minimal residual disease, and transplant-associated treatment strategies.
Solid Tumors and Precision Oncology
Investigations cover breast cancer, non-small cell lung cancer, small cell lung cancer, renal cell carcinoma, urothelial carcinoma, ovarian cancer, melanoma, prostate cancer, and gastrointestinal cancers, with emphasis on HER2, EGFR, KRAS G12C, PIK3CA, and homologous recombination repair alterations.
- Breast cancer and biomarker-defined subtypes
- Lung cancer and thoracic malignancies
- Genomically selected solid tumors
Work also extends to antibody-drug conjugates, checkpoint inhibitor-based regimens, and other targeted approaches in advanced malignancy.
Cardiovascular and Metabolic Disease
Clinical interests include atherosclerotic cardiovascular disease, acute myocardial infarction, atrial fibrillation, heart failure, hypertension, pulmonary hypertension, hypertriglyceridemia, and obesity, alongside selected studies in cardiac amyloidosis and thrombotic risk.
- Ischemic and structural heart disease
- Cardiorenal and vascular risk conditions
- Metabolic and lipid disorders
Therapeutic focus includes prevention of cardiovascular events, management of cardiorenal syndrome, and treatment of metabolic complications linked to chronic disease.
Hepatology, Autoimmunity, and Immune-Mediated Disorders
Research spans primary biliary cholangitis, primary sclerosing cholangitis, cirrhosis, acute-on-chronic liver failure, hepatocellular carcinoma, and alcohol-related liver disease, together with immune-mediated conditions such as Crohn’s disease, ulcerative colitis, systemic lupus erythematosus, rheumatoid arthritis, psoriatic arthritis, and atopic dermatitis.
- Cholestatic and chronic liver disease
- Inflammatory bowel disease
- Autoimmune and autoinflammatory disorders
Additional therapeutic interests include pruritus, fatigue and cognitive symptoms in cholestatic disease, and immune dysregulation associated with systemic inflammatory illness.
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