Markus P.
- Country
- Germany
- Department
- na
Research Overview
- A study to evaluate the safety and effectiveness of inhaled nintedanib in patients with idiopathic pulmonary fibrosis
- Phase IIb Randomized, Placebo‑Controlled Study of Oral AZD8965 on Forced Vital Capacity in Patients with Idiopathic Pulmonary Fibrosis
- A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of the Safety, Tolerability and Efficacy of Caveolin-1-Scaffolding-Protein-Derived Peptide (LTI-03) in Patients with Idiopathic Pulmonary Fibrosis (RENEW)
Data & Insights
Has run more than one trial at 12 of 73 partner sites.
Specializations
Thoracic Oncology
Clinical research activity is centered on non-small cell lung cancer, with strong involvement in biomarker-defined disease such as EGFR-mutated NSCLC, ALK-positive NSCLC, RET fusion-positive NSCLC, and KRAS G12C-mutant NSCLC. The portfolio also includes small cell lung cancer, large-cell neuroendocrine carcinoma, pleural mesothelioma, and other advanced thoracic malignancies.
- Advanced and metastatic NSCLC
- Targeted therapy in oncogene-driven lung cancer
- Small cell and neuroendocrine lung cancers
- Pleural mesothelioma
- Perioperative and adjuvant lung cancer treatment
Research interests also extend to locally advanced and resectable lung cancer, including settings where systemic treatment is integrated with surgery or radiotherapy.
Pulmonary Fibrosis and Interstitial Lung Disease
Another major focus is idiopathic pulmonary fibrosis and broader progressive pulmonary fibrosis, including chronic fibrotic lung disease with declining respiratory function. The investigator is also involved in studies addressing pulmonary hypertension associated with interstitial lung disease.
- Idiopathic pulmonary fibrosis
- Progressive pulmonary fibrosis
- Fibrotic interstitial lung disease
- Pulmonary hypertension in interstitial lung disease
This area reflects a therapeutic interest in chronic, progressive lung disorders with limited treatment options.
Pulmonary Hypertension and Pulmonary Vascular Disease
The clinical research profile includes pulmonary arterial hypertension, pulmonary hypertension, and related pulmonary vascular disease, with attention to functional capacity, disease progression, and long-term management. Studies also cover chronic thromboembolic pulmonary hypertension and combined postcapillary and precapillary pulmonary hypertension.
- Pulmonary arterial hypertension
- Pulmonary hypertension associated with lung disease
- Chronic thromboembolic pulmonary hypertension
- Combined postcapillary and precapillary pulmonary hypertension
- Exercise capacity in pulmonary vascular disease
Therapeutic interest extends across disease-modifying approaches and inhaled treatments for vascular and cardiopulmonary complications.
Chronic Airway and Inflammatory Lung Disease
Clinical trial involvement also includes chronic obstructive pulmonary disease, asthma with type 2 inflammation, bronchiectasis, refractory chronic cough, and alpha-1 antitrypsin deficiency. These studies reflect a therapeutic interest in obstructive and inflammatory respiratory disease across adult pulmonary care.
- Chronic obstructive pulmonary disease
- Type 2 inflammatory asthma
- Bronchiectasis
- Chronic cough
- Alpha-1 antitrypsin deficiency
Research activity in this area includes conditions linked to airway inflammation, mucus clearance impairment, and chronic respiratory symptoms.
Granulomatous and Rare Pulmonary Disorders
The investigator is engaged in studies of pulmonary sarcoidosis and broader chronic pulmonary sarcoidosis, as well as other uncommon respiratory disorders. This includes interest in immune-mediated lung disease and rare pulmonary conditions with persistent inflammatory burden.
- Pulmonary sarcoidosis
- Chronic pulmonary sarcoidosis
- Rare inflammatory lung disease
- Unexplained chronic respiratory symptoms
Additional involvement spans selected thoracic and pulmonary indications where novel therapeutic options are being evaluated.
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