Frank L. R.
- Country
- Germany
- Department
- Klinik für Neurochirurgie
Research Overview
Data & Insights
Has run more than one trial at 2 of 25 partner sites.
Specializations
Neuro-oncology and central nervous system tumors
The clinical research profile includes a strong focus on neurosurgical oncology, with involvement in malignant and aggressive tumors of the brain and spinal cord, including glioblastoma, medulloblastoma, ependymoma, primary central nervous system lymphoma, and atypical teratoid/rhabdoid tumours.
- Glioblastoma
- Medulloblastoma
- Primary central nervous system lymphoma
- Spinal and intracranial tumors
Research activity also extends to recurrent and high-risk pediatric and adult neuro-oncologic disease, with interest in treatment innovation across difficult-to-manage brain tumors.
Hematologic malignancies and cellular therapies
Another major area of interest is hematology-oncology, especially acute leukemias, lymphomas, and multiple myeloma, with a particular emphasis on advanced relapsed or refractory disease.
- Acute myeloid leukemia
- Acute lymphoblastic leukemia
- Diffuse large B-cell lymphoma
- Multiple myeloma
The portfolio also includes CAR T-cell therapy, gene-modified T cells, and transplant-related hematologic care, reflecting involvement in advanced immunotherapeutic approaches for blood cancers.
Neurodegenerative and neuromuscular disorders
The investigator is also involved in clinical research on disorders affecting the nervous system and muscle, including multiple sclerosis, spinal muscular atrophy, Duchenne muscular dystrophy, and selected forms of dementia.
- Multiple sclerosis
- Spinal muscular atrophy
- Duchenne muscular dystrophy
- Neurocognitive disorders
This area also includes rare inherited neurologic conditions such as Friedreich’s ataxia and Angelman syndrome, broadening the therapeutic scope within neurologic disease.
Transplant medicine, kidney disease, and immune-mediated disorders
Clinical activity includes solid organ transplantation, kidney transplantation, and immune complications such as antibody-mediated rejection, graft-versus-host disease, and chronic inflammatory renal conditions.
- Kidney transplant rejection
- Chronic kidney disease
- Glomerular disease
- Transplant-associated immune complications
Research also covers primary sclerosing cholangitis, primary biliary cholangitis, and other immune-mediated organ disorders, indicating a broad interest in inflammatory and transplant-related therapeutics.
Cardiovascular, metabolic, and critical care conditions
The investigator’s portfolio includes studies in cardiovascular disease, atrial fibrillation, myocardial infarction, heart failure, and stroke, alongside metabolic and intensive care-related conditions.
- Atrial fibrillation
- Acute ischemic stroke
- Heart failure
- Intensive care medicine
Additional interests include type 2 diabetes, obesity, and severe systemic illness, supporting a therapeutic profile that spans acute and chronic disease management.
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